Comparison of rostral spread of lumbosacral epidural volume calculated by body weight or length of the vertebral column in small-sized anesthetized dogs.

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2023-07-01
Flavio A V Freitag, Alexander Valverde, Monica Jensen, Andrea Sanchez, Diego E Gomez, Craig Bailey
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Abstract

The first objective of this prospective, randomized, crossover experimental trial was to compare the rostral spread of lumbosacral epidural volume calculated by body weight (BW) or vertebral column length (LE) in 6 small, isoflurane-anesthetized female beagle dogs (BW: 7.5 to 10.2 kg; LE measured from the occipital crest to the sacrococcygeal space: 46 to 56 cm). The second objective was to assess the response to a noxious stimulus once the dogs recovered from anesthesia and to determine the effects of the injection on cardiopulmonary variables. While in sternal position, dogs were injected through an epidural catheter with a volume mixture of bupivacaine 0.25% and iopamidol 15% based on BW: 0.2 mL/kg or LE: 0.05 mL/cm (< 50 cm) or 0.07 mL/cm (50 to < 70 cm). Rostral spread was determined by counting the number of vertebrae reached by iopamidol using computed tomography. After anesthesia, cardiopulmonary variables, motor function, and responses to nociceptive stimuli were evaluated. Comparisons were completed with mixed linear models and 2-way analysis of variance (ANOVA) (P < 0.05). The volume of injectate (3.29 ± 0.74 versus 1.81 ± 0.21 mL; mean ± SD) and the number of vertebrae (22 ± 2 versus 19 ± 2 vertebrae) reached by iopamidol were significantly greater for LE than for BW. Response to nociception, time to return of pain sensation, motor function, and cardiopulmonary variables were similar between groups. In conclusion, dosing based on LE resulted in larger rostral spread than when based on BW in dogs of small size.

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小型麻醉犬体质量与脊柱长度计算腰骶部硬膜外容积吻侧展布的比较。
这项前瞻性、随机、交叉试验的第一个目的是比较6只小的、异氟醚麻醉的雌性比格犬(BW: 7.5 ~ 10.2 kg;从枕嵴到骶尾骨间隙测量LE: 46 ~ 56 cm)。第二个目的是评估狗从麻醉中恢复后对有害刺激的反应,并确定注射对心肺变量的影响。在犬处于胸骨位时,通过硬膜外导管注射布比卡因0.25%和iopamidol 15%的体积混合物,根据BW: 0.2 mL/kg或LE: 0.05 mL/cm (< 50 cm)或0.07 mL/cm(50至< 70 cm)。通过计算使用计算机断层扫描的iopamidol到达的椎骨数量来确定吻侧扩散。麻醉后,评估心肺变量、运动功能和对伤害性刺激的反应。采用混合线性模型和双因素方差分析(ANOVA)完成比较(P < 0.05)。注射体积(3.29±0.74 vs 1.81±0.21 mL);平均±SD)和经iopamidol达到的椎骨数(22±2对19±2)显著大于BW。对伤害感觉的反应、疼痛感觉恢复时间、运动功能和心肺变量在两组之间相似。综上所述,在体型较小的犬中,基于LE的剂量比基于体重的剂量导致更大的吻侧扩散。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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