Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation.

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-01-01 Epub Date: 2023-08-31 DOI:10.1080/15548627.2023.2252265

Zhiya Deng, Man He, Hongbin Hu, Wenqian Zhang, Yaoyuan Zhang, Yue Ge, Tongtong Ma, Jie Wu, Lulan Li, Maomao Sun, Sheng An, Jiaxin Li, Qiaobing Huang, Shenhai Gong, Jiaxing Zhang, Zhongqing Chen, Zhenhua Zeng

引用次数: 0

Abstract

Abbreviations: AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff staining; RTECs: renal tubular epithelial cells; SAKI: sepsis-induced acute kidney injury; Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A, mitochondrial; TMRE: tetramethylrhodamine.

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褪黑素通过SIRT3介导的TFAM去乙酰化促进有丝分裂，从而减轻败血症诱发的急性肾损伤。

缩写：缩写： AKI：急性肾损伤；ATP：三磷酸腺苷；BUN：血尿素氮；CLP：盲肠结扎和穿刺；eGFR：估计肾小球滤过率；H&E：苏木精和伊红染色；LCN2/NGAL：脂钙蛋白 2；LPS：脂多糖；LTL：荷花四腺凝集素；mKeima：PAS：周期性酸-希夫染色；RTECs：肾小管上皮细胞；SAKI：败血症诱发的急性肾损伤；Scr：血清肌酐；SIRT3：sirtuin 3；TFAM：线粒体转录因子 A；TMRE：四甲基罗丹明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.