Longitudinal hippocampal atrophy in hippocampal sclerosis of aging

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2023-01-01 DOI:10.1016/j.nbas.2023.100092
Janice X. Li , Hannah L. Nguyen , Tianchen Qian , Davis C. Woodworth , S. Ahmad Sajjadi , for the Alzheimer's Disease Neuroimaging Initiative
{"title":"Longitudinal hippocampal atrophy in hippocampal sclerosis of aging","authors":"Janice X. Li ,&nbsp;Hannah L. Nguyen ,&nbsp;Tianchen Qian ,&nbsp;Davis C. Woodworth ,&nbsp;S. Ahmad Sajjadi ,&nbsp;for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.nbas.2023.100092","DOIUrl":null,"url":null,"abstract":"<div><p>Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older individuals and is associated with dementia. HS-A is characterized by disproportionate hippocampal atrophy at autopsy but cannot be diagnosed during life. Therefore, little is known about the onset and progression of hippocampal atrophy in individuals with HS-A. To better understand the onset and progression of hippocampal atrophy in HS-A, we examined longitudinal hippocampal atrophy using serial MRI in participants with HS-A at autopsy (HS-A+, n = 8) compared to participants with limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) without HS-A (n = 13), Alzheimer’s disease neuropathologic change (ADNC) without HS-A or LATE-NC (n = 16), and those without these pathologies (n = 7). We found that participants with HS-A had lower hippocampal volumes compared to the other groups, and this atrophy preceded the onset of dementia. There was also some evidence that rates of hippocampal volume loss were slightly slower in those with HS-A. Together, these results suggest that the disproportionate hippocampal atrophy seen in HS-A may begin early prior to dementia.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/17/main.PMC10448324.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging brain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589958923000294","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older individuals and is associated with dementia. HS-A is characterized by disproportionate hippocampal atrophy at autopsy but cannot be diagnosed during life. Therefore, little is known about the onset and progression of hippocampal atrophy in individuals with HS-A. To better understand the onset and progression of hippocampal atrophy in HS-A, we examined longitudinal hippocampal atrophy using serial MRI in participants with HS-A at autopsy (HS-A+, n = 8) compared to participants with limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) without HS-A (n = 13), Alzheimer’s disease neuropathologic change (ADNC) without HS-A or LATE-NC (n = 16), and those without these pathologies (n = 7). We found that participants with HS-A had lower hippocampal volumes compared to the other groups, and this atrophy preceded the onset of dementia. There was also some evidence that rates of hippocampal volume loss were slightly slower in those with HS-A. Together, these results suggest that the disproportionate hippocampal atrophy seen in HS-A may begin early prior to dementia.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
老年海马硬化的海马纵向萎缩
衰老性海马硬化症(HS-A)是老年人常见的退行性神经病理学,与痴呆症有关。HS-A的特征是尸检时海马过度萎缩,但在生活中无法诊断。因此,对HS-A患者海马萎缩的发生和发展知之甚少。为了更好地了解HS-A患者海马萎缩的发生和进展,我们在尸检时使用系列MRI检查了患有HS-A的参与者(HS-A+,n=8)的纵向海马萎缩,与患有边缘型占主导地位的年龄相关性TDP-43脑病神经病理学改变(LATE-NC)的参与者(n=13)相比,没有HS-A或LATE-NC的阿尔茨海默病神经病理学改变(ADNC)(n=16),以及没有这些病理的阿尔茨海默病(n=7)。我们发现,与其他组相比,患有HS-A的参与者的海马体积较低,这种萎缩发生在痴呆症发作之前。也有一些证据表明,HS-A患者的海马体积损失率略慢。总之,这些结果表明,HS-A中出现的不成比例的海马萎缩可能在痴呆之前就开始了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
自引率
0.00%
发文量
0
期刊最新文献
Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles Innate immunity in brain aging and neurodegeneration Neural correlates of home-based intervention effects on value-based sequential decision-making in healthy older adults
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1