Longitudinal hippocampal atrophy in hippocampal sclerosis of aging

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2023-01-01 DOI:10.1016/j.nbas.2023.100092
Janice X. Li , Hannah L. Nguyen , Tianchen Qian , Davis C. Woodworth , S. Ahmad Sajjadi , for the Alzheimer's Disease Neuroimaging Initiative
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引用次数: 1

Abstract

Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older individuals and is associated with dementia. HS-A is characterized by disproportionate hippocampal atrophy at autopsy but cannot be diagnosed during life. Therefore, little is known about the onset and progression of hippocampal atrophy in individuals with HS-A. To better understand the onset and progression of hippocampal atrophy in HS-A, we examined longitudinal hippocampal atrophy using serial MRI in participants with HS-A at autopsy (HS-A+, n = 8) compared to participants with limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) without HS-A (n = 13), Alzheimer’s disease neuropathologic change (ADNC) without HS-A or LATE-NC (n = 16), and those without these pathologies (n = 7). We found that participants with HS-A had lower hippocampal volumes compared to the other groups, and this atrophy preceded the onset of dementia. There was also some evidence that rates of hippocampal volume loss were slightly slower in those with HS-A. Together, these results suggest that the disproportionate hippocampal atrophy seen in HS-A may begin early prior to dementia.

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老年海马硬化的海马纵向萎缩
衰老性海马硬化症(HS-A)是老年人常见的退行性神经病理学,与痴呆症有关。HS-A的特征是尸检时海马过度萎缩,但在生活中无法诊断。因此,对HS-A患者海马萎缩的发生和发展知之甚少。为了更好地了解HS-A患者海马萎缩的发生和进展,我们在尸检时使用系列MRI检查了患有HS-A的参与者(HS-A+,n=8)的纵向海马萎缩,与患有边缘型占主导地位的年龄相关性TDP-43脑病神经病理学改变(LATE-NC)的参与者(n=13)相比,没有HS-A或LATE-NC的阿尔茨海默病神经病理学改变(ADNC)(n=16),以及没有这些病理的阿尔茨海默病(n=7)。我们发现,与其他组相比,患有HS-A的参与者的海马体积较低,这种萎缩发生在痴呆症发作之前。也有一些证据表明,HS-A患者的海马体积损失率略慢。总之,这些结果表明,HS-A中出现的不成比例的海马萎缩可能在痴呆之前就开始了。
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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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