Curcumin's effect on serum zinc, copper and magnesium levels in obese individuals.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-05-01 DOI:10.22038/AJP.2022.21517

Maryam Saberi-Karimian, Arezoo Orooji, Niloofar Taghizadeh, Mansoureh Sadat Ekhteraee Toosi, Gordon A Ferns, Malihe Aghasizadeh, Majid Ghayour-Mobarhan

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Abstract

Objective: The obesity prevalence is growing worldwide. There is strong evidence indicating that a disturbance of zinc, copper and magnesium concentrations is associated with the development of obesity and its related diseases. Our aim was to determine the effect of curcumin supplementation on serum zinc, magnesium and copper in obese individuals.

Materials and methods: In this randomized crossover trial study, thirty obese patients with an age range of 18 to 65 years were randomized to treatment with curcumin 1 g/day or placebo for 30 days. There was then a two-week wash-out period, after which, subjects crossed to the alternate regimen. Serum levels of zinc, copper and magnesium were determined at baseline and at the end of the study.

Results: The study groups were similar to each other in base line characteristics. We did not observe significant impacts (p>0.05) of curcumin on Cu, Zn, Mg serum concentrations.

Conclusion: Curcumin administration at a dose of 1 g/day for 30 days did not affect serum Cu, Zn, Mg levels in obese subjects.

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姜黄素对肥胖个体血清锌、铜和镁水平的影响。

目的：肥胖的流行率在全球范围内呈上升趋势。有强有力的证据表明，锌、铜和镁浓度的紊乱与肥胖及其相关疾病的发展有关。我们的目的是确定补充姜黄素对肥胖个体血清锌、镁和铜的影响。材料和方法：在这项随机交叉试验研究中，30名年龄在18至65岁之间的肥胖患者被随机接受姜黄素1g/天或安慰剂治疗30天。然后有一个为期两周的洗去期，之后，受试者转入替代方案。在基线和研究结束时测定血清锌、铜和镁水平。结果：研究组基线特征相似。我们没有观察到姜黄素对Cu、Zn、Mg血清浓度的显著影响（p>0.05）。结论：姜黄素以1g/天的剂量给药30天不会影响肥胖受试者的血清Cu、Zn、Mg水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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