A New Calculation Model for Calcium Requirements After Parathyroidectomy in Patients With Secondary Hyperparathyroidism.

IF 2.9 3区医学 Q1 OTORHINOLARYNGOLOGY Clinical and Experimental Otorhinolaryngology Pub Date : 2023-08-01 DOI:10.21053/ceo.2023.00584

Ming Cheng, Qian Zhang, Mengjing Wang, Bihong Huang, Ye Tao, Chunyan Fan, Hongying Wang, Minmin Zhang

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Abstract

Objectives: We aimed to develop a new calculation model for calcium requirements in dialysis patients following parathyroidectomy.

Methods: A total of 98 patients with secondary hyperparathyroidism receiving parathyroidectomy from January 2014 to January 2022 were enrolled in this study. Among these patients, 78 were randomly selected for construction of the calcium requirement calculation model, and the remaining 20 patients were selected for model validation. The calcium requirement model estimated the total calcium supplementation for 1 week after surgery using variables with significant relationships in the derivation group by stepwise multiple linear regression analysis. Bias, precision, and accuracy were measured in the validation group to determine the performance of the model.

Results: The model was as follows: calcium requirement for 1 week after surgery=33.798-8.929×immediate postoperative calcium+0.190×C-reactive protein-0.125×age+0.002×preoperative intact parathyroid hormone+0.003×preoperative alkaline phosphatase (R2=0.8). The model was successfully validated.

Conclusion: We generated a novel model to guide calcium supplementation. This model can assist in stabilizing the serum calcium levels of patients during the early postoperative period. Furthermore, it contributes to the individualized and precise treatment of hypocalcemia in patients following parathyroidectomy.

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继发性甲状旁腺功能亢进患者甲状旁腺切除术后钙需要量的新计算模型。

目的:建立一种新的甲状旁腺切除术后透析患者钙需要量计算模型。方法:选取2014年1月至2022年1月接受甲状旁腺切除术的继发性甲状旁腺功能亢进患者98例。其中随机选取78例建立钙需求计算模型，剩余20例进行模型验证。钙需取量模型采用衍生组中有显著关系的变量，通过逐步多元线性回归分析，估计术后1周的总补钙量。在验证组中测量偏倚、精密度和准确度，以确定模型的性能。结果:模型为:术后1周钙需取量=33.798-8.929×immediate术后钙+0.190×C-reactive protein-0.125×age+0.002×preoperative完整甲状旁腺激素+0.003×preoperative碱性磷酸酶(R2=0.8)。模型得到了成功的验证。结论:我们建立了一个新的钙补充指导模型。该模型有助于稳定术后早期患者的血钙水平。此外，它有助于个体化和精确治疗甲状旁腺切除术后患者的低钙。

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来源期刊

Clinical and Experimental Otorhinolaryngology 医学-耳鼻喉科学

CiteScore

4.90

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Otorhinolaryngology (Clin Exp Otorhinolaryngol, CEO) is an international peer-reviewed journal on recent developments in diagnosis and treatment of otorhinolaryngology-head and neck surgery and dedicated to the advancement of patient care in ear, nose, throat, head, and neck disorders. This journal publishes original articles relating to both clinical and basic researches, reviews, and clinical trials, encompassing the whole topics of otorhinolaryngology-head and neck surgery. CEO was first issued in 2008 and this journal is published in English four times (the last day of February, May, August, and November) per year by the Korean Society of Otorhinolaryngology-Head and Neck Surgery. The Journal aims at publishing evidence-based, scientifically written articles from different disciplines of otorhinolaryngology field. The readership contains clinical/basic research into current practice in otorhinolaryngology, audiology, speech pathology, head and neck oncology, plastic and reconstructive surgery. The readers are otolaryngologists, head and neck surgeons and oncologists, audiologists, and speech pathologists.