Cognition in patients with post-bariatric hypoglycemia

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2023-09-05 DOI:10.1002/oby.23862

Alexa Puleio, Amanda Sheehan, Gail Musen, Mary Elizabeth Patti

{"title":"Cognition in patients with post-bariatric hypoglycemia","authors":"Alexa Puleio, Amanda Sheehan, Gail Musen, Mary Elizabeth Patti","doi":"10.1002/oby.23862","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Bariatric surgery, a highly effective treatment for obesity and associated comorbidities, may improve cognition and brain volume in parallel with cardiometabolic function. However, some post-bariatric individuals develop post-bariatric hypoglycemia (PBH), which can be frequent and severe. The impact of recurrent hypoglycemia on cognition in PBH is unknown. The objective of this study was to determine whether individuals with PBH display reduced cognitive function compared with postsurgical counterparts without hypoglycemia.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Fourteen adults with a history of Roux-en-Y gastric bypass with hypoglycemia (PBH+, <i>n</i> = 7) or without PBH (PBH−, <i>n</i> = 7) completed assessments of memory, executive function, attention, and psychomotor speed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>PBH+ individuals displayed significantly decreased performance in category fluency (<i>p</i> < 0.01), category switching (<i>p</i> < 0.01), and category switching accuracy (<i>p</i> < 0.01), compared with PBH− individuals. Performance in the first (<i>p</i> = 0.03) and third intervals (<i>p</i> = 0.045) of verbal fluency was significantly lower in PBH+ individuals versus PBH− individuals. All other assessments did not differ.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>PBH+ individuals may be at greater risk for cognitive impairment compared with PBH− individuals, as suggested by impaired semantic processing and cognitive flexibility, as well as greater difficulty initiating and sustaining word retrieval.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 3","pages":"466-471"},"PeriodicalIF":4.2000,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.23862","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Bariatric surgery, a highly effective treatment for obesity and associated comorbidities, may improve cognition and brain volume in parallel with cardiometabolic function. However, some post-bariatric individuals develop post-bariatric hypoglycemia (PBH), which can be frequent and severe. The impact of recurrent hypoglycemia on cognition in PBH is unknown. The objective of this study was to determine whether individuals with PBH display reduced cognitive function compared with postsurgical counterparts without hypoglycemia.

Methods

Fourteen adults with a history of Roux-en-Y gastric bypass with hypoglycemia (PBH+, n = 7) or without PBH (PBH−, n = 7) completed assessments of memory, executive function, attention, and psychomotor speed.

Results

PBH+ individuals displayed significantly decreased performance in category fluency (p < 0.01), category switching (p < 0.01), and category switching accuracy (p < 0.01), compared with PBH− individuals. Performance in the first (p = 0.03) and third intervals (p = 0.045) of verbal fluency was significantly lower in PBH+ individuals versus PBH− individuals. All other assessments did not differ.

Conclusions

PBH+ individuals may be at greater risk for cognitive impairment compared with PBH− individuals, as suggested by impaired semantic processing and cognitive flexibility, as well as greater difficulty initiating and sustaining word retrieval.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肥胖后低血糖患者的认知。

目的：减肥手术是治疗肥胖和相关合并症的高效方法，可以在改善心脏代谢功能的同时提高认知能力和脑容量。然而，一些减肥后个体会出现减肥后低血糖（PBH），这可能是频繁和严重的。PBH患者反复低血糖对认知的影响尚不清楚。本研究的目的是确定与没有低血糖的术后患者相比，PBH患者的认知功能是否降低。方法：14例有Roux-en-Y胃转流术史并伴有低血糖（PBH+ = 7）或不含PBH（PBH-，n = 7）完成对记忆力、执行功能、注意力和心理运动速度的评估。结果：PBH+个体在类别流利性方面表现出显著下降（p 结论：与PBH-个体相比，PBH+个体可能面临更大的认知障碍风险，这表明语义处理和认知灵活性受损，以及启动和维持单词检索的难度更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.

期刊最新文献

Issue Information Poster Abstracts Oral Abstracts Issue Information Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system