Shared Genetic Factors Contributing to the Overlap between Attention-Deficit/Hyperactivity Disorder Symptoms and Overweight/Obesity in Swedish Adolescent Girls and Boys.

IF 1 4区 医学 Q4 GENETICS & HEREDITY Twin Research and Human Genetics Pub Date : 2022-12-01 DOI:10.1017/thg.2022.35
Kristin N Javaras, Melissa A Munn-Chernoff, Elizabeth W Diemer, Laura M Thornton, Cynthia M Bulik, Zeynap Yilmaz, Paul Lichtenstein, Henrik Larsson, Jessica H Baker
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引用次数: 2

Abstract

Attention-deficit/hyperactivity disorder (ADHD) and obesity are positively associated, with increasing evidence that they share genetic risk factors. Our aim was to examine whether these findings apply to both types of ADHD symptoms for female and male adolescents. We used data from 791 girl and 735 boy twins ages 16-17 years to examine sex-specific phenotypic correlations between the presence of ADHD symptoms and overweight/obese status. For correlations exceeding .20, we then fit bivariate twin models to estimate the genetic and environmental correlations between the presence of ADHD symptoms and overweight/obese status. ADHD symptoms and height/weight were parent- and self-reported, respectively. Phenotypic correlations were .30 (girls) and .08 (boys) for inattention and overweight/obese status and .23 (girls) and .14 (boys) for hyperactivity/impulsivity and overweight/obese status. In girls, both types of ADHD symptoms and overweight/obese status were highly heritable, with unique environmental effects comprising the remaining variance. Furthermore, shared genetic effects explained most of the phenotypic correlations in girls. Results suggest that the positive association of both types of ADHD symptoms with obesity may be stronger in girls than boys. Further, in girls, these associations may stem primarily from shared genetic factors.

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共同的遗传因素导致瑞典青少年男女注意力缺陷/多动障碍症状和超重/肥胖之间的重叠。
注意力缺陷/多动障碍(ADHD)和肥胖呈正相关,越来越多的证据表明它们具有相同的遗传风险因素。我们的目的是检验这些发现是否适用于女性和男性青少年的两种类型的ADHD症状。我们使用了791名16-17岁的女孩和735名男孩双胞胎的数据来检查ADHD症状与超重/肥胖状态之间的性别特异性表型相关性。对于超过0.20的相关性,我们拟合双变量双胞胎模型来估计ADHD症状与超重/肥胖状态之间的遗传和环境相关性。ADHD症状和身高/体重分别由父母和自己报告。注意力不集中和超重/肥胖状态的表型相关性分别为0.30(女孩)和0.08(男孩),多动/冲动和超重/肥胖状态的表型相关性分别为0.23(女孩)和0.14(男孩)。在女孩中,两种类型的ADHD症状和超重/肥胖状态都是高度遗传的,独特的环境影响包括剩余的方差。此外,共享的遗传效应解释了女孩中大多数的表型相关性。结果表明,两种类型的ADHD症状与肥胖的正相关在女孩中可能比男孩更强。此外,在女孩中,这些关联可能主要源于共同的遗传因素。
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来源期刊
Twin Research and Human Genetics
Twin Research and Human Genetics 医学-妇产科学
CiteScore
1.50
自引率
11.10%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.
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