{"title":"What Is Next for Connexin and Pannexin?","authors":"Timothy M Sveeggen, Anna Kosmach, Pooneh Bagher","doi":"10.1159/000533281","DOIUrl":null,"url":null,"abstract":"Signaling across membranes is vital for tissue and organ function throughout the body. This is achieved through careful regulation of transmembrane channels allowing for passage of ions and second messengers to and from the cytosol and intracellular compartments, which can generate electrical impulses and trigger signaling cascades. Connexins and pannexins are among the most versatile transmembrane channel proteins, which shape cell behavior and tissue function with extraordinary finesse. In this volume, pannexins and connexins 37, 40, and 43 are reviewed [1–4], with special consideration for tissue specificity of expression, cell type-specific functions, and their roles in development and disease.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":"60 2","pages":"69-72"},"PeriodicalIF":1.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570909/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vascular Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000533281","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
Signaling across membranes is vital for tissue and organ function throughout the body. This is achieved through careful regulation of transmembrane channels allowing for passage of ions and second messengers to and from the cytosol and intracellular compartments, which can generate electrical impulses and trigger signaling cascades. Connexins and pannexins are among the most versatile transmembrane channel proteins, which shape cell behavior and tissue function with extraordinary finesse. In this volume, pannexins and connexins 37, 40, and 43 are reviewed [1–4], with special consideration for tissue specificity of expression, cell type-specific functions, and their roles in development and disease.
期刊介绍：
The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.
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