Neck Ganglioneuroma Mimicking a Thyroid Nodule in a Four-Year-Old Child: A Case Report and Review of the Literature.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM International Journal of Endocrinology and Metabolism Pub Date : 2023-04-01 DOI:10.5812/ijem-126486
Stefania Corrado, Cesare Morgante, Sauro Tassi, Francesco Maccarrone, Gianluca Di Massa, Alfredo Pontecorvi, Giampaolo Papi
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Abstract

Introduction: Ganglioneuromas are tumors of neurogenic origin usually located in the abdomen, the adrenal glands, and the mediastinum but infrequently found in the neck region.

Case presentation: We describe the case of a four-year-old Albanian girl presenting with an anterior neck mass initially suspected to be a thyroid nodule. From a clinical point of view, there was no evidence of compression on vital cervical structures. Lab tests detected normal serum thyrotropin, calcitonin, and parathormone concentrations. A neck ultrasound showed a huge mass apparently originating from the left thyroid lobe. Cytological examination of fine needle biopsy demonstrated a population of large cells with eosinophilic cytoplasm, regular nuclei, and prominent nucleoli and spindle cells without significant atypia, consistent with a benign lesion of neurogenic origin. Also, the neck MRI displayed a mass with well-defined margins, likely arising from the peripheral nervous system. The patient underwent surgical excision of the mass without complications. The histological exam was diagnostic for ganglioneuroma.

Conclusions: We discuss the cytological and histological features peculiar to such a rare neck lesion and review the differential diagnosis.

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1例4岁儿童颈部神经节神经瘤伴甲状腺结节:1例报告及文献复习。
神经节神经瘤是一种神经源性肿瘤,通常位于腹部、肾上腺和纵隔,但很少发生在颈部。病例介绍:我们描述了一个四岁的阿尔巴尼亚女孩的情况下,提出了一个前颈部肿块最初怀疑是甲状腺结节。从临床角度来看,没有证据表明颈椎重要结构受到压迫。实验室检测血清促甲状腺素、降钙素和甲状旁腺激素浓度正常。颈部超音波显示一巨大肿块,明显源自左甲状腺叶。细针活检细胞学检查显示大细胞群嗜酸性细胞质,细胞核规则,核仁和梭形细胞突出,无明显异型性,符合神经源性良性病变。同时,颈部MRI显示肿块边界清晰,可能来自周围神经系统。患者接受手术切除肿块,无并发症。组织学检查诊断为神经节神经瘤。结论:我们讨论了这种罕见的颈部病变的细胞学和组织学特征,并回顾了鉴别诊断。
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CiteScore
3.10
自引率
4.80%
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0
期刊介绍: The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.
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