Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-06-15 DOI:10.1037/bne0000561
Samantha M Smith, Elena L Garcia, Anna Montelongo, Caroline G Davidson, Denna Bakhtiar, Sarah D Lovett, Andrew P Maurer, Sara N Burke
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引用次数: 0

Abstract

Improving cognitive health for older adults requires understanding the neurobiology of age-related cognitive decline and the mechanisms underlying preserved cognition in old age. During spatial learning tasks, aged humans and rodents shift navigation preferences in favor of a stimulus-response learning strategy. This has been hypothesized to result from competitive interactions of the caudate nucleus/dorsal striatum (DS) memory system with the hippocampus (HPC)-dependent spatial/allocentric memory system. In support of this hypothesis, a recent study reported that inactivation of the DS in aged rodents rescued HPC-dependent spatial learning on a T-maze (Gardner, Gold, & Korol, 2020). Currently, it is unclear whether a shift from HPC-dependent to DS-dependent behavior also contributes to age-related cognitive decline outside of spatial learning and memory. To test the hypothesis that inactivation of the DS can restore age-related cognitive function outside of spatial behavior, the present study bilaterally inactivated the DS of young (n = 8) and aged (n = 7) rats during visuospatial paired associates learning (PAL). This study found that inactivation of the DS did not alter PAL performance in young or aged rats, but did alter a positive control, DS-dependent spatial navigation task. This observation suggests that elevated DS activity does not play a role in the decline of HPC-dependent PAL performance in aged male rats. Given the persistent tendencies of aged rodents toward DS-dependent learning, it will be worthwhile to explore further the coordination dynamics between the HPC and DS that may contribute to age-related cognitive decline. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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麝香草酚对幼年和老年雄性大鼠背侧纹状体的失活作用不会影响配对联想学习能力。
要改善老年人的认知健康,就必须了解与年龄相关的认知衰退的神经生物学以及老年期认知保持的内在机制。在空间学习任务中,老年人类和啮齿类动物会改变导航偏好,转而采用刺激-反应学习策略。据推测,这是尾状核/背侧纹状体(DS)记忆系统与依赖海马(HPC)的空间/全中心记忆系统竞争性相互作用的结果。为了支持这一假说,最近的一项研究报告称,在老龄啮齿类动物中使尾状核/背侧纹状体(DS)失活可挽救 T 型迷宫中依赖 HPC 的空间学习(Gardner、Gold 和 Korol,2020 年)。目前,还不清楚从依赖 HPC 到依赖 DS 的行为转变是否也会导致空间学习和记忆以外的与年龄相关的认知能力下降。为了验证 DS 失活能恢复与年龄相关的空间行为以外的认知功能这一假设,本研究在视觉空间配对联想学习(PAL)过程中对年轻大鼠(n = 8)和老年大鼠(n = 7)的 DS 进行了双侧失活。该研究发现,DS 失活不会改变幼鼠或老龄鼠的 PAL 表现,但会改变阳性对照、依赖 DS 的空间导航任务。这一观察结果表明,DS活性的升高并不会导致老年雄性大鼠依赖HPC的PAL表现下降。鉴于老年啮齿类动物持续倾向于依赖DS的学习,因此值得进一步探索HPC和DS之间的协调动态,这可能会导致与年龄相关的认知能力下降。(PsycInfo Database Record (c) 2023 APA, 版权所有)。
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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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