Alamira Farah Alwiraikat-Flores, Pablo Octavio-Aguilar
{"title":"Calcium regulation by SERC-A before and during Alzheimer disease","authors":"Alamira Farah Alwiraikat-Flores, Pablo Octavio-Aguilar","doi":"10.7705/biomedica.6704","DOIUrl":null,"url":null,"abstract":"<p><p>There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease.\nThis review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 1","pages":"51-60"},"PeriodicalIF":0.8000,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476880/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7705/biomedica.6704","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"TROPICAL MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease.
This review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function.
期刊介绍：
Biomédica is the quarterly journal of the Instituto Nacional de Salud of Colombia [Colombias National Health Institute]. Its purpose is to publish the results of original research that contributes meaningfully to knowledge in health and biomedical sciences.
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