{"title":"Analysis of Specificity and Distribution Characteristics of Red Blood Cell Irregular Antibodies.","authors":"Hui Ni, Xiaoye Sun, Hui Cong","doi":"10.1093/labmed/lmac160","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The presence of red blood cell (RBC) irregular antibodies can severely jeopardize mother and child and bring trouble to the treatment of anemia. The aim of this study was to analyze the specificity of RBC irregular antibody in inpatients.</p><p><strong>Methods: </strong>An analysis was performed on samples from patients with RBC irregular antibodies. Antibody screening positive samples were analyzed.</p><p><strong>Results: </strong>Among the 778 cases of irregular antibody positive samples, 214 were from males and 564 from females. History of blood transfusion accounted for 13.1% of the total. Of the women, 96.8% had a pregnancy. A total of 131 antibodies were identified. The antibodies included 68 Rh systematic antibodies, 6 MNS systematic antibodies, 6 Lewis systematic antibodies, 2 Kidd systematic antibodies, 10 autoantibodies, and 39 antibodies of uncertain specificity.</p><p><strong>Conclusion: </strong>Patients with blood transfusion or pregnancy history are prone to produce RBC irregular antibodies.</p>","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"507-511"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/labmed/lmac160","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The presence of red blood cell (RBC) irregular antibodies can severely jeopardize mother and child and bring trouble to the treatment of anemia. The aim of this study was to analyze the specificity of RBC irregular antibody in inpatients.
Methods: An analysis was performed on samples from patients with RBC irregular antibodies. Antibody screening positive samples were analyzed.
Results: Among the 778 cases of irregular antibody positive samples, 214 were from males and 564 from females. History of blood transfusion accounted for 13.1% of the total. Of the women, 96.8% had a pregnancy. A total of 131 antibodies were identified. The antibodies included 68 Rh systematic antibodies, 6 MNS systematic antibodies, 6 Lewis systematic antibodies, 2 Kidd systematic antibodies, 10 autoantibodies, and 39 antibodies of uncertain specificity.
Conclusion: Patients with blood transfusion or pregnancy history are prone to produce RBC irregular antibodies.
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