Efficacy of a polylactic acid matrix for the closure of Wagner grade 1 and 2 diabetic foot ulcers: a single-center, prospective randomized trial.

IF 1.4 4区医学 Q3 DERMATOLOGY Wounds : a compendium of clinical research and practice Pub Date : 2023-08-01

Brock A Liden, José L Ramirez-GarciaLuna

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引用次数: 0

Abstract

Introduction: CAMPs are used for treating refractory DFUs where other treatments have failed. PLA is a CAMP that has demonstrated effectiveness in promoting healing in burns and acute wounds.

Objective: A single-center, prospective, randomized controlled trial comparing PLA-guided closure matrices versus collagen dressings was conducted to assess healing of Wagner grades 1 and 2 DFUs.

Materials and methods: A total of 30 participants were randomized to receive weekly debridement, wound care, and DFU offloading plus either PLA or collagen CAMPs. The primary outcome was the time to achieve full healing, and the secondary outcome was the proportion of ulcers healed at 12 weeks.

Results: The median time to achieve full healing was 9.3 ± 2.9 weeks in the PLA group versus 14.8 ± 8.1 weeks in the collagen group (P = .021), representing a 44% reduction in the time to heal. Furthermore, by 12 weeks, 80% of the PLA-treated ulcers were healed compared to only 33% in the collagen group (P = .025).

Conclusion: The results of this study show PLA matrices induce a potent healing response that leads to reduced healing time and an increased OR for achieving healing by 12 weeks.

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聚乳酸基质封闭瓦格纳 1 级和 2 级糖尿病足溃疡的疗效：单中心前瞻性随机试验。

简介：CAMPs 可用于治疗其他疗法无效的难治性 DFU。聚乳酸是一种 CAMP，已被证明能有效促进烧伤和急性伤口的愈合：一项单中心、前瞻性、随机对照试验比较了聚乳酸引导的闭合基质和胶原敷料，以评估瓦格纳1级和2级DFU的愈合情况：共有 30 名参与者被随机分配到接受每周清创、伤口护理和 DFU 卸载以及聚乳酸或胶原蛋白 CAMPs。主要结果是达到完全愈合的时间，次要结果是12周时溃疡愈合的比例：结果：聚乳酸组达到完全愈合的中位时间为（9.3 ± 2.9）周，而胶原蛋白组为（14.8 ± 8.1）周（P = .021），愈合时间缩短了 44%。此外，到 12 周时，80% 的聚乳酸处理溃疡已愈合，而胶原蛋白组仅为 33%（P = .025）：本研究结果表明，聚乳酸基质能诱导有效的愈合反应，从而缩短愈合时间，并提高 12 周内愈合的成功率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.