Meta-analysis of haematocrit and activated partial thromboplastin time as risk factors for unplanned interruptions in patients undergoing continuous renal replacement therapy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.1177/03913988231180639

Kun Zhang, Chunxia Liu, Heling Zhao

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Abstract

Objective: Although continuous renal replacement therapy (CRRT) is common, unplanned interruptions often limit its usefulness. Unplanned interruption refers to the forced interruption of blood purification treatment, the failure to complete blood purification treatment goals or the failure to meet blood purification schedule times. This study aimed to evaluate the effect of haematocrit and activated partial thromboplastin time (APTT) on the incidence of unplanned interruptions in critical patients with CRRT.

Methods: A systematic review and a meta-analysis were performed by searching the databases of China National Knowledge Infrastructure, Wanfang, VIP, China Biomedical Literature, Cochrane Library, PubMed, Web of Science and Embase from their inception to 31st March 2022 for all studies with a comparator or independent variable relating to the unplanned interruption of CRRT.

Results: Nine studies involving 1165 participants were included. Haematocrit and APTT were independent risk factors for the unplanned interruption of CRRT. The higher the haematocrit level, the greater the risk of unplanned CRRT interruptions (relative risk ratio [RR] = 1.04, 95% confidence interval [CI]: 1.02, 1.07, Z = 4.27, p < 0.001). The prolongation of APPT reduced the risk of unplanned CRRT interruptions (RR = 0.94, 95% CI: 0.92, 0.96, Z = 6.10, p < 0.001).

Conclusion: Haematocrit and APTT are the influencing factors on the incidence of unplanned interruptions in critical patients undergoing CRRT.

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红细胞压积和活化部分凝血活酶时间作为持续肾替代治疗患者意外中断的危险因素的荟萃分析。

目的:虽然持续肾替代治疗(CRRT)是常见的，意外中断往往限制其有效性。计划外中断是指血液净化治疗被迫中断，未能完成血液净化治疗目标或未能满足血液净化计划时间。本研究旨在评估红细胞压积和活化部分凝血活素时间(APTT)对危重CRRT患者意外中断发生率的影响。方法:通过检索中国国家知识基础设施、万方、维普、中国生物医学文献、Cochrane图书馆、PubMed、Web of Science和Embase等数据库，从建库至2022年3月31日，对所有与CRRT意外中断相关的比较物或自变量进行系统评价和meta分析。结果:纳入9项研究，共1165名受试者。红细胞压积和APTT是CRRT计划外中断的独立危险因素。红细胞压积水平越高，CRRT意外中断的风险越大(相对风险比[RR] = 1.04, 95%可信区间[CI]: 1.02, 1.07, Z = 4.27, p Z = 6.10, p)结论:红细胞压积和APTT是危重患者CRRT意外中断发生率的影响因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.