Lipoprotein-Associated Phospholipase A2 Correlates with Reduced Left Ventricle Ejection Fraction in Hemodialysis Patients.

Laboratory medicine Pub Date : 2023-09-05 DOI:10.1093/labmed/lmac162

Chen Jun-Feng, Jin Xiao-Ping, Zhang Juan, Yang Man-Li, Liu Fan, Fu Peng, Wu Qi-Shun, Shu Yang, Si Bo-Lin, Hu Yu-Wen, Chen Liang

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Abstract

Objective: Reduced left ventricular ejection fraction (LVEF) is common in hemodialysis (HD) patients. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered an important determinant of cardiovascular events. The aim of the study was to evaluate the relationship between Lp-PLA2 and LVEF in HD patients.

Methods: Fifty-seven HD patients with coronary heart disease were enrolled. Predialysis and postdialysis venous whole blood samples were collected. The patients were divided into preserved and reduced LVEF groups. The relationship between Lp-PLA2 and LVEF was assessed.

Results: A significant difference in C-reactive protein (CRP) and Lp-PLA2 was observed, with higher levels noted in patients with reduced LVEF (P ≤ .001). Both Lp-PLA2 and CRP were negatively correlated with LVEF in the HD patients. Only Lp-PLA2 remained associated with LVEF in multiple regression analysis.

Conclusion: Lipoprotein-associated phospholipase A2 levels are associated with LVEF and could potentially be used to evaluate chronic heart failure with reduced LVEF in HD patients for risk stratification management.

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脂蛋白相关磷脂酶A2与血液透析患者左心室射血分数降低相关

目的:左室射血分数(LVEF)降低在血液透析(HD)患者中很常见。脂蛋白相关磷脂酶A2 (Lp-PLA2)被认为是心血管事件的重要决定因素。该研究的目的是评估HD患者Lp-PLA2与LVEF之间的关系。方法:纳入57例合并冠心病的HD患者。采集透析前和透析后静脉全血样本。将患者分为LVEF保留组和LVEF减少组。评估Lp-PLA2与LVEF的关系。结果:c -反应蛋白(CRP)和Lp-PLA2在两组患者中有显著性差异，且LVEF降低的患者CRP和Lp-PLA2水平较高(P≤0.001)。HD患者Lp-PLA2、CRP与LVEF均呈负相关。多元回归分析显示，只有Lp-PLA2与LVEF存在相关性。结论:脂蛋白相关磷脂酶A2水平与LVEF相关，可用于评估HD患者慢性心力衰竭伴LVEF降低的风险分层管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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