18F-FDG PET/CT Versus 68Ga-PSMA-11 PET/CT in Evaluation of Distant Metastatic Disease in Recurrent Renal Cell Carcinoma.

IF 1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of nuclear medicine technology Pub Date : 2023-09-01 DOI:10.2967/jnmt.122.264014
Rahul V Parghane, Sandip Basu
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引用次数: 0

Abstract

Prostate-specific membrane antigen (PSMA) expression has been observed in the neovasculature of various malignancies. We present a case of metastatic renal cell carcinoma (RCC) with comparative 18F-FDG PET/CT and 68Ga-PSMA-11 imaging in which FDG PET/CT failed to detect metastatic thyroid disease and showed less 18F-FDG-concentrating lesions at other sites, whereas 68Ga-PSMA-11 PET/CT identified metastatic thyroid disease and demonstrated intensely 68Ga-PSMA-11-expressing distant metastatic lesions. 68Ga-PSMA-11 PET/CT may be considered a potentially useful imaging technique in RCC to detect metastasis and to guide the choice of specific treatments, such as PSMA-based radionuclide therapy in patients with recurrent metastatic RCC.

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18F-FDG PET/CT与68Ga-PSMA-11 PET/CT对复发性肾细胞癌远处转移的评价
前列腺特异性膜抗原(PSMA)在多种恶性肿瘤的新生血管中均有表达。我们报告了一例转移性肾细胞癌(RCC)的18F-FDG PET/CT和68Ga-PSMA-11成像的比较,其中FDG PET/CT未能检测到转移性甲状腺疾病,并且在其他部位显示较少的18F-FDG集中病变,而68Ga-PSMA-11 PET/CT识别了转移性甲状腺疾病,并显示强烈表达68Ga-PSMA-11的远处转移病变。68Ga-PSMA-11 PET/CT可能被认为是RCC检测转移和指导特定治疗选择的潜在有用的成像技术,例如复发转移性RCC患者的psma为基础的放射性核素治疗。
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来源期刊
Journal of nuclear medicine technology
Journal of nuclear medicine technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.90
自引率
15.40%
发文量
57
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