Role and therapeutic target of P2X2/3 receptors in visceral pain

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuropeptides Pub Date : 2023-10-01 DOI:10.1016/j.npep.2023.102355

Hong-mei Luo , Jia-rong Ye , Fan-qin Pu , Hong-liang Luo , Wen-jun Zhang

引用次数: 1

Abstract

Visceral pain (VP) is caused by internal organ disease. VP is involved in nerve conduction and related signaling molecules, but its specific pathogenesis has not yet been fully elucidated. Currently, there are no effective methods for treating VP. The role of P2X2/3 in VP has progressed. After visceral organs are subjected to noxious stimulation, cells release ATP, activate P2X2/3, enhance the sensitivity of peripheral receptors and the plasticity of neurons, enhance sensory information transmission, sensitize the central nervous system, and play an important role in the development of VP. However, antagonists possess the pharmacological effect of relieving pain. Therefore, in this review, we summarize the biological functions of P2X2/3 and discuss the intrinsic link between P2X2/3 and VP. Moreover, we focus on the pharmacological effects of P2X2/3 antagonists on VP therapy and provide a theoretical basis for its targeted therapy.

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P2X2/3受体在内脏疼痛中的作用及治疗靶点

内脏疼痛（VP）是由内脏疾病引起的。VP参与神经传导和相关信号分子，但其具体发病机制尚未完全阐明。目前尚无有效的治疗VP的方法。P2X2/3在VP中的作用已取得进展。内脏器官受到伤害性刺激后，细胞释放ATP，激活P2X2/3，增强外周受体的敏感性和神经元的可塑性，增强感觉信息传递，使中枢神经系统敏感，在VP的发展中发挥重要作用。然而，拮抗剂具有止痛的药理作用。因此，在这篇综述中，我们总结了P2X2/3的生物学功能，并讨论了P2X2-3与VP之间的内在联系。此外，我们还重点研究了P2X2/3拮抗剂对VP治疗的药理作用，为其靶向治疗提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.