Association between H-type Hypertension and White Matter Hyperintensity in Patients with Acute Ischemic Stroke.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Current neurovascular research Pub Date : 2023-01-01 DOI:10.2174/1567202620666230522153438

Jiawei Yang, Zhiyong Cao, Jiahu Jiang, Yong Zhou, Xiangyang Zhu

{"title":"Association between H-type Hypertension and White Matter Hyperintensity in Patients with Acute Ischemic Stroke.","authors":"Jiawei Yang, Zhiyong Cao, Jiahu Jiang, Yong Zhou, Xiangyang Zhu","doi":"10.2174/1567202620666230522153438","DOIUrl":null,"url":null,"abstract":"Objective: White matter hyperintensity (WMH) is related to the increased risk of ischemic stroke. It is unclear if H-type hypertension (H-type HBP) is associated with periventricular WMH (PWMH) and deep WMH (DWMH) of acute ischemic stroke. This study investigated the correlation between H-type HBP and the severity of PWMH and DWMH in acute ischemic stroke.Methods: Consecutive patients with acute ischemic stroke were included in this cross-sectional observational study. The patients were divided into the following groups: the normal group, the simple hypertension group (Simple HBP), the simple hyperhomocysteinemia group (Simple HHcy) and the H-type HBP group. MR imaging and relevant clinical variables were obtained from the medical records. PWMH and DWMH were rated by using the Fazekas scale (score 0-3). All patients were defined to have moderate-severe PWMH or DWMH (score 2-3) and no or mild group (score 0-1). Multivariate binary logistic regression analysis was performed to determine the relationship between H-type HBP and the severity of PWMH and DWMH.Results: Among 542 patients, 227 had moderate-severe PWMH and 228 had moderate-severe DWMH. Compared to the no or mild group, patients with moderate-severe PWMH (median age: 73 vs. 63 years) and DWMH (median age: 70 vs. 65.5 years) were older. Compared to the no or mild group, moderate-severe PWMH and DWMH were associated with a history of ischemic stroke (moderate-severe PWMH vs. no or mild group 20.7% vs. 11.7%, p = 0.004；moderatesevere DWMH vs. no or mild group 20.2% vs. 12.1%, p = 0.010); We found that H-type HBP was an independent risk factor for PWMH (OR 2.64, 95% CI 1.34-5.21) and DWMH (OR 3.64, 95% CI 1.82-7.26) after adjusting for the effect of relevant risk factors.Conclusion: This study suggests that H-type HBP is associated with the severity of PWMH and DWMH in acute ischemic stroke patients, which deserves further prevention measures.","PeriodicalId":10879,"journal":{"name":"Current neurovascular research","volume":"20 2","pages":"190-196"},"PeriodicalIF":2.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current neurovascular research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1567202620666230522153438","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: White matter hyperintensity (WMH) is related to the increased risk of ischemic stroke. It is unclear if H-type hypertension (H-type HBP) is associated with periventricular WMH (PWMH) and deep WMH (DWMH) of acute ischemic stroke. This study investigated the correlation between H-type HBP and the severity of PWMH and DWMH in acute ischemic stroke.

Methods: Consecutive patients with acute ischemic stroke were included in this cross-sectional observational study. The patients were divided into the following groups: the normal group, the simple hypertension group (Simple HBP), the simple hyperhomocysteinemia group (Simple HHcy) and the H-type HBP group. MR imaging and relevant clinical variables were obtained from the medical records. PWMH and DWMH were rated by using the Fazekas scale (score 0-3). All patients were defined to have moderate-severe PWMH or DWMH (score 2-3) and no or mild group (score 0-1). Multivariate binary logistic regression analysis was performed to determine the relationship between H-type HBP and the severity of PWMH and DWMH.

Results: Among 542 patients, 227 had moderate-severe PWMH and 228 had moderate-severe DWMH. Compared to the no or mild group, patients with moderate-severe PWMH (median age: 73 vs. 63 years) and DWMH (median age: 70 vs. 65.5 years) were older. Compared to the no or mild group, moderate-severe PWMH and DWMH were associated with a history of ischemic stroke (moderate-severe PWMH vs. no or mild group 20.7% vs. 11.7%, p = 0.004；moderatesevere DWMH vs. no or mild group 20.2% vs. 12.1%, p = 0.010); We found that H-type HBP was an independent risk factor for PWMH (OR 2.64, 95% CI 1.34-5.21) and DWMH (OR 3.64, 95% CI 1.82-7.26) after adjusting for the effect of relevant risk factors.

Conclusion: This study suggests that H-type HBP is associated with the severity of PWMH and DWMH in acute ischemic stroke patients, which deserves further prevention measures.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

急性缺血性脑卒中患者h型高血压与白质高强度的关系

目的:脑白质高强度(WMH)与缺血性脑卒中风险增加有关。目前尚不清楚h型高血压(h型HBP)是否与急性缺血性卒中的心室周围WMH (PWMH)和深部WMH (DWMH)相关。本研究探讨急性缺血性脑卒中患者h型血压与PWMH、DWMH严重程度的相关性。方法:连续急性缺血性脑卒中患者纳入横断面观察性研究。将患者分为正常组、单纯性高血压组(simple HBP)、单纯性高同型半胱氨酸血症组(simple HHcy)和h型HBP组。从病历中获取磁共振成像和相关临床变量。采用Fazekas量表对PWMH和DWMH进行评分(分值0-3)。所有患者被定义为中重度PWMH或DWMH(评分2-3)，无或轻度组(评分0-1)。采用多元二元logistic回归分析确定h型高血压与PWMH和DWMH严重程度的关系。结果:542例患者中，中重度PWMH 227例，中重度DWMH 228例。与无或轻度组相比，中重度PWMH(中位年龄:73岁vs. 63岁)和DWMH(中位年龄:70岁vs. 65.5岁)患者年龄更大。与无或轻度组相比，中重度PWMH和DWMH与缺血性卒中史相关(中重度PWMH vs无或轻度组20.7% vs 11.7%， p = 0.004;中重度DWMH vs无或轻度组20.2% vs 12.1%， p = 0.010);在调整相关危险因素的影响后，我们发现h型高血压是PWMH (OR 2.64, 95% CI 1.34-5.21)和DWMH (OR 3.64, 95% CI 1.82-7.26)的独立危险因素。结论:本研究提示h型血压与急性缺血性脑卒中患者PWMH和DWMH的严重程度相关，值得进一步预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current neurovascular research 医学-临床神经学

CiteScore

3.80

自引率

9.50%

发文量

审稿时长

3 months

期刊介绍： Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.