Telomere length is associated with increased risk of cutaneous melanoma: a Mendelian randomization study.

IF 1.5 4区 医学 Q3 DERMATOLOGY Melanoma Research Pub Date : 2023-12-01 Epub Date: 2023-08-25 DOI:10.1097/CMR.0000000000000917
Mingjuan Liu, Yining Lan, Hanlin Zhang, Xinyi Zhang, Mengyin Wu, Leyan Yang, Jia Zhou, Meiyi Tong, Ling Leng, Heyi Zheng, Jun Li, Xia Mi
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Abstract

Results: The MR analysis using two TL GWAS datasets revealed strong and consistent evidence that long TL is causally associated with an increased risk of CM. The analysis of the Codd et al. dataset found that long TL significantly predicted an elevated risk of CM (IVW OR = 2.411, 95% CI 2.092-2.780, P = 8.05E-34). Similarly, the analysis of the Li et al. dataset yielded consistent positive results across all MR methods, providing further robustness to the causal relationship (IVW OR = 2.324, 95% CI 1.516-3.565, P = 1.11E-04). The study provides evidence for a causal association between TL and CM susceptibility, indicating that longer TL increases the risk of developing CM and providing insight into the unique telomere biology in melanoma pathogenesis. Telomere maintenance pathways may be a potential target for preventing and treating CM.

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端粒长度与皮肤黑色素瘤风险增加相关:一项孟德尔随机化研究。
结果:使用两个TL GWAS数据集的MR分析显示,有强有力且一致的证据表明,长TL与CM风险增加有因果关系。Codd等人的数据集分析发现,长TL显著预测CM风险增加(IVW OR=2.411,95%CI 2.092-2.780,P=8.05E-34)。类似地,对Li等人数据集的分析在所有MR方法中产生了一致的阳性结果,为因果关系提供了进一步的稳健性(IVW OR=2.324,95%CI 1.516-3.565,P=1.11E-04)。该研究为TL和CM易感性之间的因果关系提供证据,表明较长的TL增加了发展为CM的风险,并为了解黑色素瘤发病机制中独特的端粒生物学提供了见解。端粒维持途径可能是预防和治疗CM的潜在靶点。
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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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