Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma

Q4 Medicine Revista Espanola de Patologia Pub Date : 2023-07-01 DOI:10.1016/j.patol.2023.02.005

Enrico Escobar , Fernán Gómez-Valenzuela , Cristian Peñafiel , Alondra Hormazábal-Hevia , Constanza Herrera-Fuentes , Diana Mori-Aliaga

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Abstract

Introduction

Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC.

Objective

Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC.

Material and methods

The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls.

Results

COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (p < 0.05). Bax expression was lower in poorly differentiated OSCC (p < 0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (p < 0.05).

Conclusion

There are immunohistochemical differences according to histological grades of OSCC, which could influence clinical behavior.

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COX-2、Ki-67、Bcl-2、Bax、VEGF和CD105在口腔鳞状细胞癌组织学分级中的免疫组织化学表达

口腔鳞状细胞癌（OSCC）是癌症最常见的肿瘤。很少有研究根据OSCC的组织学分级来分析炎症相关蛋白（COX-2）和肿瘤进展的表达。目的根据OSCC组织学分级分析COX-2、Ki-67（细胞增殖）、Bcl-2/Bax（细胞凋亡）、VEGF和CD105（血管生成）的免疫组化表达。材料和方法，对58例OSCC患者的Ki-67、Bcl-2、Bax、VEGF和CD105进行分析。以13例口腔黏膜（OM）为对照。结果COX-2、VEGF、CD105和Ki-67在OSCC中的表达高于OM，特别是在低分化OSCC中（p＜0.05）。Bax在低分化的OSCC中表达较低（p＜0.001），这可能影响临床行为。

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