Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre-eclampsia

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY Fundamental & Clinical Pharmacology Pub Date : 2023-08-31 DOI:10.1111/fcp.12952

Rebecca Reddy, Sooraj Baijnath, Sanil Singh, Roshila Moodley, Thajasvarie Naicker, Nalini Govender

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Abstract

Background

Hesperidin, a flavanone commonly found in citrus fruits and herbal formulations, has emerged as a potential new therapeutic agent for modulating several diseases. Since pre-eclampsia is a growing public health threat, it may negatively impact the economy and increase the disease burden of South Africa. Phytocompounds are easily accessible, demonstrate minimal side effects, and may confer novel medicinal options as a treatment and preventive preference.

Objective

To investigate the physiological, biochemical, and hematological outcomes of hesperidin in an arginine vasopressin (AVP)-induced rodent model of pre-eclampsia.

Methods

Female Sprague–Dawley rats were surgically implanted with mini-osmotic pumps to deliver AVP (200 ng/h) subcutaneously. Animals were treated with hesperidin at 200 mg/kg.b.w via oral gavage for 14 days. Systolic and diastolic blood pressures were measured on GD 7, 14, and 18 using a non-invasive tail-cuff method and were euthanized on GD 21.

Results

The findings showed that hesperidin administration significantly decreased blood pressure (P < 0.05) and urinary protein levels in pregnant rats (P < 0.001). Placental and individual pup weight also increased significantly in the pregnant hesperidin-treated groups compared to AVP untreated groups (P < 0.001). Biochemical and hematological markers such as white blood cell count and lymphocyte levels differed significantly (P < 0.05) in AVP groups treated with and without hesperidin.

Conclusion

Our results suggest that hesperidin is an antihypertensive agent with modes of action associated with its diuretic and blood pressure lowering effects and reduction of proteinuria in AVP-induced pre-eclamptic rats.

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橙皮甙能改善精氨酸加压素先兆子痫大鼠模型的生理结果。

背景：橙皮甙是一种常见于柑橘类水果和草药配方中的黄烷酮，已成为调节多种疾病的潜在新治疗剂。由于先兆子痫对公共健康的威胁日益严重，它可能会对南非的经济造成负面影响，并增加疾病负担。植物化合物容易获得，副作用小，可作为治疗和预防的新药物选择：目的：研究橙皮甙在精氨酸加压素（AVP）诱导的子痫前期啮齿动物模型中的生理、生化和血液学结果：雌性 Sprague-Dawley 大鼠经手术植入微型渗透泵，皮下注射 AVP（200 纳克/小时）。大鼠经口灌胃服用200毫克/千克体重的橙皮甙，连续14天。在第 7、14 和 18 个生长期使用无创尾套法测量收缩压和舒张压，在第 21 个生长期对动物实施安乐死：结果表明，服用橙皮甙能显著降低血压（P 结论：橙皮甙能降低血压：我们的研究结果表明，橙皮甙是一种降压药，其作用模式与利尿、降压和减少蛋白尿有关，适用于 AVP 诱导的前子痫大鼠。

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来源期刊

Fundamental & Clinical Pharmacology 医学-药学

CiteScore

5.30

自引率

6.90%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Fundamental & Clinical Pharmacology publishes reports describing important and novel developments in fundamental as well as clinical research relevant to drug therapy. Original articles, short communications and reviews are published on all aspects of experimental and clinical pharmacology including: Antimicrobial, Antiviral Agents Autonomic Pharmacology Cardiovascular Pharmacology Cellular Pharmacology Clinical Trials Endocrinopharmacology Gene Therapy Inflammation, Immunopharmacology Lipids, Atherosclerosis Liver and G-I Tract Pharmacology Metabolism, Pharmacokinetics Neuropharmacology Neuropsychopharmacology Oncopharmacology Pediatric Pharmacology Development Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics, Pharmacogenomics Pharmacovigilance Pulmonary Pharmacology Receptors, Signal Transduction Renal Pharmacology Thrombosis and Hemostasis Toxicopharmacology Clinical research, including clinical studies and clinical trials, may cover disciplines such as pharmacokinetics, pharmacodynamics, pharmacovigilance, pharmacoepidemiology, pharmacogenomics and pharmacoeconomics. Basic research articles from fields such as physiology and molecular biology which contribute to an understanding of drug therapy are also welcomed.