Congenital cleft lip and palate and elevated risks of major psychiatric disorders: A nationwide longitudinal study.

IF 1.8 4区医学 Q3 PSYCHIATRY Clinical Child Psychology and Psychiatry Pub Date : 2024-04-01 Epub Date: 2023-09-08 DOI:10.1177/13591045231200665

Hsiang-Hsuan Huang, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Shih-Jen Tsai, Mu-Hong Chen

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Abstract

Background: Congenital cleft lip and palate (CCLP) may be associated with major psychiatric disorders, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, bipolar disorder, and major depressive disorder.

Methods: From the Taiwan National Health Insurance Research Database, 1,158 children and adolescents with CCLP and 11,580 age/sex-matched controls without CCLP were included in this study between 2001 and 2010; they were followed up until the end of 2011 to identify the aforementioned major psychiatric disorders.

Results: After adjustment for age, sex, income, residence, and family history, the Cox regression model revealed a positive relationship of CCLP with subsequent schizophrenia (hazard ratio [HR]: 7.60, 95% confidence interval [CI]: 2.03-28.54), ASD (HR: 6.03, 95% CI: 1.76-20.61), and ADHD (HR: 7.33, 95% CI: 5.01-10.73).

Discussion: These findings suggest that clinicians should be attentive to the presence or emergence of mental health conditions in patients with CCLP. Further studies are necessary to investigate the pathogenesis between CCLP and major psychiatric disorders.

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先天性唇腭裂与主要精神障碍的高风险：一项全国性纵向研究。

背景：先天性唇腭裂（CCLP）可能与自闭症谱系障碍（ASD）、注意缺陷多动障碍（ADHD）、精神分裂症、躁郁症和重度抑郁症等主要精神疾病有关：方法：本研究从台湾国民健康保险研究数据库中选取了2001年至2010年间的1158名患有CCLP的儿童和青少年以及11580名年龄/性别匹配的未患有CCLP的对照者，对他们进行随访至2011年底，以确定上述主要精神障碍：结果：在对年龄、性别、收入、居住地和家族史进行调整后，Cox 回归模型显示，CCLP 与精神分裂症（危险比 [HR]：7.60，95% 置信区间 [CI]：2.03-28.54）、自闭症（HR：6.03，95% 置信区间 [CI]：1.76-20.61）和多动症（HR：7.33，95% 置信区间 [CI]：5.01-10.73）呈正相关：讨论：这些研究结果表明，临床医生应注意 CCLP 患者是否存在或出现精神健康问题。有必要进一步研究 CCLP 与主要精神疾病之间的发病机制。

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来源期刊

Clinical Child Psychology and Psychiatry PSYCHIATRY-PSYCHOLOGY

CiteScore

3.60

自引率

5.60%

发文量

130

期刊介绍： Clinical Child Psychology and Psychiatry brings together clinically oriented, peer reviewed work of the highest distinction from an international and multidisciplinary perspective, offering comprehensive coverage of clinical and treatment issues across the range of treatment modalities. Clinical Child Psychology and Psychiatry is interested in advancing theory, practice and clinical research in the realm of child and adolescent psychology and psychiatry and related disciplines. The journal directs its attention to matters of clinical practice, including related topics such as the ethics of treatment and the integration of research into practice. Multidisciplinary in approach, the journal includes work by, and is of interest to, child psychologists, psychiatrists and psychotherapists, nurses, social workers and all other professionals in the fields of child and adolescent psychology and psychiatry.