Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation.

IF 2.5 3区医学 Q2 UROLOGY & NEPHROLOGY Investigative and Clinical Urology Pub Date : 2023-09-01 DOI:10.4111/icu.20220402

Seung-Hun Song, Tae Ho Lee, Young Sun Her, Mihee Oh, Dong Hyuk Shin, Yohan Heo, Dae Keun Kim, Dong Suk Kim

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Abstract

Purpose: We compared semen quality and sperm DNA fragmentation in cancer patients who underwent sperm banking and controls who underwent sperm cryopreservation for assisted reproductive technology (ART).

Materials and methods: A total of 132 men, 65 cancer patients and 67 controls, were prospectively enrolled and performed sperm cryopreservation for fertility preservation from May 2019 to February 2021. Sperm quality was determined by measuring semen volume, sperm concentration, sperm motility, and sperm DNA fragmentation index (DFI). Sperm quality and sperm DFI were compared in cancer patients and controls.

Results: The major cancers of the 65 cancer patients were leukemia (26.2%), testicular cancer (23.1%), and lymphoma (20.0%). Sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls. Sperm DFI was significantly higher in cancer patients than in controls (24.32%±15.69% vs. 19.11%±11.63%; p=0.033). After excluding 8 cancer patients who received chemotherapy before sperm banking, sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls, but there was no significant difference in sperm DFI for cancer patients and controls (23.14%±12.79% vs. 19.11%±11.63%; p=0.069).

Conclusions: Sperm quality was lower in cancer patients than in controls. There was no difference in the sperm DFI of cancer patients prior to chemotherapy and men presenting for sperm cryopreservation for ART. We recommend that all men who are planning cancer therapy should be offered sperm banking prior to gonadotoxic chemotherapy as a standard of fertility preservation.

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接受精子冷冻保存的癌症患者的精液质量和精子DNA断裂。

目的:我们比较了接受精子库的癌症患者和接受精子冷冻保存以辅助生殖技术(ART)的对照患者的精液质量和精子DNA断裂。材料与方法:2019年5月至2021年2月，前瞻性纳入132名男性，65名癌症患者和67名对照组，并进行精子冷冻保存以保存生育能力。通过测量精液体积、精子浓度、精子活力和精子DNA碎片指数(DFI)来确定精子质量。比较癌症患者和对照组的精子质量和精子DFI。结果:65例肿瘤患者中以白血病(26.2%)、睾丸癌(23.1%)、淋巴瘤(20.0%)为主。癌症患者的精子浓度、精子总能动性和精子进行性能动性明显低于对照组。肿瘤患者精子DFI明显高于对照组(24.32%±15.69% vs. 19.11%±11.63%;p = 0.033)。在排除了8例在精子库前接受化疗的癌症患者后，癌症患者的精子浓度、精子总活动力和精子进展活动力均显著低于对照组，但癌症患者与对照组的精子DFI无显著差异(23.14%±12.79% vs. 19.11%±11.63%;p = 0.069)。结论:肿瘤患者精子质量低于对照组。化疗前癌症患者的精子DFI与为ART进行精子冷冻保存的男性的精子DFI没有差异。我们建议所有计划癌症治疗的男性在使用促性腺毒素化疗之前进行精子库治疗，以此作为保留生育能力的标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative and Clinical Urology Medicine-Urology

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

4 weeks

期刊介绍： Investigative and Clinical Urology (Investig Clin Urol, ICUrology) is an international, peer-reviewed, platinum open access journal published bimonthly. ICUrology aims to provide outstanding scientific and clinical research articles, that will advance knowledge and understanding of urological diseases and current therapeutic treatments. ICUrology publishes Original Articles, Rapid Communications, Review Articles, Special Articles, Innovations in Urology, Editorials, and Letters to the Editor, with a focus on the following areas of expertise: • Precision Medicine in Urology • Urological Oncology • Robotics/Laparoscopy • Endourology/Urolithiasis • Lower Urinary Tract Dysfunction • Female Urology • Sexual Dysfunction/Infertility • Infection/Inflammation • Reconstruction/Transplantation • Geriatric Urology • Pediatric Urology • Basic/Translational Research One of the notable features of ICUrology is the application of multimedia platforms facilitating easy-to-access online video clips of newly developed surgical techniques from the journal''s website, by a QR (quick response) code located in the article, or via YouTube. ICUrology provides current and highly relevant knowledge to a broad audience at the cutting edge of urological research and clinical practice.