Multimodal integration and modulation of visual and somatosensory inputs on the corticospinal excitability

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2023-06-01 DOI:10.1016/j.neucli.2022.102842

Fatma Gokcem Yildiz , Cagri Mesut Temucin

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Abstract

Objective

Corticospinal excitability may be affected by various sensory inputs under physiological conditions. In this study, we aimed to investigate the corticospinal excitability by using multimodal conditioning paradigms of combined somatosensory electrical and visual stimulation to understand the sensory-motor integration.

Methods

We examined motor evoked potentials (MEP) obtained by using transcranial magnetic stimulation (TMS) that were conditioned by using a single goggle–light-emitting diode (LED) stimulation, peripheral nerve electrical stimulation (short latency afferent inhibition protocol), or a combination of both (goggle-LED+electrical stimulation) at different interstimulus intervals (ISIs) in 14 healthy volunteers.

Results

We found MEP inhibition at ISIs of 50–60 ms using the conditioned goggle-LED stimulation. The combined goggle-LED stimulation at a 60 ms ISI resulted in an additional inhibition to the electrical stimulation.

Conclusions

Visual inputs cause significant modulatory effects on the corticospinal excitability. Combined visual and somatosensory stimuli integrate probably via different neural circuits and/or interneuron populations. To our knowledge, multimodal integration of visual and somatosensory inputs by using TMS-short latency inhibition protocol have been evaluated via electrophysiological methods for the first time in this study.

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视觉和体感输入对皮质脊髓兴奋性的多模式整合和调节

目的在生理条件下，皮质脊髓兴奋性可能受到各种感觉输入的影响。在这项研究中，我们旨在通过使用体感电刺激和视觉刺激的多模式条件反射范式来研究皮质脊髓的兴奋性，以了解感觉-运动整合。方法检测经颅磁刺激（TMS）获得的运动诱发电位（MEP），或两者的组合（护目镜LED+电刺激）。结果我们发现，使用条件护目镜LED刺激，MEP在50–60 ms的ISIs下受到抑制。60ms ISI的组合护目镜LED刺激导致对电刺激的额外抑制。结论视觉输入对皮质脊髓兴奋性具有显著的调节作用。视觉和体感刺激的结合可能通过不同的神经回路和/或中间神经元群体进行整合。据我们所知，本研究首次通过电生理学方法评估了使用TMS短潜伏期抑制协议对视觉和体感输入的多模式整合。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.