The influence of inflammation and frailty in the aging continuum

IF 5.3 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2023-10-01 DOI:10.1016/j.mad.2023.111872

Beatrice Arosio , Evelyn Ferri , Daniela Mari , Eleonora Tobaldini , Giovanni Vitale , Nicola Montano

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引用次数: 1

Abstract

Inflammaging is a low-grade inflammatory state that can be considered an adaptive process aimed at stimulating appropriate anti-inflammatory response. Frailty is determined by the accumulation of molecular and cellular defects accumulated throughout life; therefore, an appropriate frailty computation could be a valuable tool for measuring biological age. This study aims to analyse the association between inflammatory markers and both chronological age "per se" and frailty. We studied 452 persons aged 43–114 years. A Frailty Index (FI) was computed considering a wide range of age-related signs, symptoms, disabilities, and diseases. Plasma concentrations of inflammatory cytokines and peripheral markers of neuroinflammation were analysed by next-generation ELISA. The mean age of the cohort was 79.7 (from 43 to 114) years and the median FI was 0.19 (from 0.00 to 0.75). The concentrations of most inflammatory markers increased significantly with chronological age, after adjustment for sex and FI. Interferon-γ was significantly affected only by FI, while interleukin (IL)-10 and IL-1β were associated only with chronological age. In conclusion, we described different associations between inflammatory components and chronological vs. biological age. A better characterization of the molecular signature of aging could help to understand the complexity of this process.

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炎症和虚弱对衰老的影响。

炎症是一种低度炎症状态，可被视为一种旨在刺激适当抗炎反应的适应性过程。脆弱性是由一生中积累的分子和细胞缺陷决定的；因此，适当的脆弱性计算可能是测量生物年龄的一个有价值的工具。本研究旨在分析炎症标志物与按时间顺序排列的年龄“本身”和虚弱之间的关系。我们研究了452名年龄在43-114岁之间的人。虚弱指数（FI）的计算考虑了广泛的与年龄相关的体征、症状、残疾和疾病。通过下一代ELISA分析炎症细胞因子和神经炎症外周标志物的血浆浓度。该队列的平均年龄为79.7岁（从43岁到114岁），中位FI为0.19岁（从0.00岁到0.75岁）。在对性别和FI进行调整后，大多数炎症标志物的浓度随着年龄的增长而显著增加。干扰素-γ仅受FI的显著影响，而白细胞介素（IL）-10和IL-1β仅与年龄相关。总之，我们描述了炎症成分与时间和生物年龄之间的不同关联。更好地表征衰老的分子特征可能有助于理解这一过程的复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.