Hepatic regenerative response to long-term consumption of cinnamon-rich diet in aged rats.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-05-01 DOI:10.22038/AJP.2023.21751
Mahmoud Zardast, Samaneh Nakhaee, Mohammad Attarzadeh Firouzabadi, Mohammad Dastjerdi, Masumeh Askari, Zahra Ghiravani, Khadijeh Farrokhfall
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Abstract

Objective: The present study aimed to investigate the impact of cinnamon on liver regeneration in a rat model of partial hepatectomy (PH).

Materials and methods: Thirty-two old male Sprague-Dawley rats (12 weeks old) were randomly divided into two equal groups (n=16). One group was fed with a standard diet (control) while the other group was fed with the same diet containing 1% cinnamon for 41 weeks. Then, all animals were subjected to the PH procedure and their livers were studied on postoperative days 2, 10 and 28. The liver contents of hepatic growth factor (HGF), insulin, malondialdehyde (MDA), nitric oxide metabolites (NOx), superoxide dismutase (SOD) and tumor necrosis factor-alpha (TNF-α) were evaluated. Also, the serum levels of liver function markers (alanine aminotransferase (ALT) and aspartate aminotransferase (AST), MDA, NOx and SOD activity were measured.

Results: The regenerated liver weight was significantly higher in cinnamon-treated animals than the controls on both day 10 and 28 post hepatectomy. The hepatic MDA levels in the cinnamon-treated animals were significantly lower than the control rats. Cinnamon led to a significant increase of SOD on day 2 after hepatectomy in serum and liver content. The basal level of HGF in the liver of cinnamon-consuming rats was significantly higher than in the control rats. Hepatic insulin level was significantly increased relative to baseline and control on day 2 in the cinnamon-consuming rats. Hepatic TNF-α levels dramatically decreased on postoperative days (POD) 2 relative to baseline in the control and cinnamon-treated rats.

Conclusion: Long-term cinnamon consumption enhanced liver regeneration outcomes in old rats.

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年老大鼠长期食用富含肉桂的饮食对肝脏再生的影响。
目的:探讨肉桂对肝部分切除(PH)大鼠肝再生的影响。材料与方法:12周龄雄性sd大鼠32只,随机分为2组(n=16)。一组饲喂标准日粮(对照),另一组饲喂含有1%肉桂的日粮,为期41周。然后,对所有动物进行PH处理,并在术后第2、10和28天对其肝脏进行研究。测定肝生长因子(HGF)、胰岛素、丙二醛(MDA)、一氧化氮代谢物(NOx)、超氧化物歧化酶(SOD)和肿瘤坏死因子-α (TNF-α)含量。测定血清肝功能指标(谷丙转氨酶(ALT)和天冬氨酸转氨酶(AST))、丙二醛(MDA)、一氧化氮(NOx)和SOD活性。结果:在肝切除术后第10天和第28天,肉桂处理的动物的再生肝脏重量明显高于对照组。肉桂处理大鼠肝脏MDA水平明显低于对照大鼠。肉桂可显著提高肝切除后第2天血清和肝脏SOD含量。肉桂摄食大鼠肝脏中HGF的基础水平明显高于对照大鼠。在第2天,与基线和对照组相比,肉桂摄食大鼠的肝脏胰岛素水平显著升高。对照和肉桂处理大鼠的肝脏TNF-α水平在术后天数(POD) 2相对于基线显著下降。结论:长期食用肉桂可促进老年大鼠肝脏再生。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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