[Rapid determination of titanium in human urine by inductively coupled plasma-tandem mass spectrometry].

Wei sheng yan jiu = Journal of hygiene research Pub Date : 2023-07-01 DOI:10.19813/j.cnki.weishengyanjiu.2023.04.014

Miao Zhang, Zhifei Zhao, Liang Ding

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Abstract

Objective: To establish an inductively coupled plasma-tandem mass spectrometry(ICP-MS/MS) method to determinate the titanium(Ti) in human urine samples rapidly.

Methods: By comparing different gas mode, ~(47)Ti was selected as the analysis element. Injecting NH_3 to the collision/reaction cell, swept by mass spectrum to determine the optimal mass spectrum conditions with the mass number of Q1=47, Q2=149(Ti ammonia hexamer). The mass spectrometry conditions of internal standard elements, integration time, reaction gas flow rate and data processing method and so on were optimized.

Results: Ti had a good linear between 0.1-5.00 μg/L under the optimal analytical conditions. The detection limit was 0.1 μg/L. The RSDs of intra-day and inter-day were less than 10%, and the average recoveries were 93.7%-112.2%. The result of Seronorm Trace Elements Urine L-2 met the acceptable range.

Conclusion: The method is rapid, simple, accuracy, and suitable for the rapid analysis of titanium in human urine.

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电感耦合等离子串联质谱法快速测定人尿中钛

目的:建立电感耦合等离子体串联质谱(ICP-MS/MS)快速测定人体尿液中钛(Ti)的方法。方法:通过对不同气相的比较，选择~(47)Ti作为分析元素。将NH_3注入碰撞/反应池，通过质谱扫描确定最佳质谱条件，质量数Q1=47, Q2=149(Ti -氨六聚体)。对内标元素的质谱条件、积分时间、反应气流量、数据处理方法等进行了优化。结果:在最佳分析条件下，Ti在0.1 ~ 5.00 μg/L范围内呈良好的线性关系。检出限为0.1 μg/L。日内、日间的rsd < 10%，平均加样回收率为93.7% ~ 112.2%。血清微量元素尿L-2检测结果符合可接受范围。结论:该方法快速、简便、准确，适用于人尿中钛的快速分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Wei sheng yan jiu = Journal of hygiene research

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