Therapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders.

IF 2.7 4区医学 Q3 NEUROSCIENCES CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI:10.2174/1871527322666230718105358

Neeraj Kumar Sethiya, Neha Ghiloria, Akanksha Srivastav, Dheeraj Bisht, Sushil Kumar Chaudhary, Vaibhav Walia, Md Sabir Alam

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Abstract

Myricetin (MC), 3,5,7,3',4',5'-hexahydroxyflavone, chemically belongs to a flavonoid category known to confer antioxidant, antimicrobial, antidiabetic, and neuroprotective effects. MC is known to suppress the generation of Reactive Oxygen Species (ROS), lipid peroxidation (MDA), and inflammatory markers. It has been reported to improve insulin function in the human brain and periphery. Besides this, it modulates several neurochemicals including glutamate, GABA, serotonin, etc. MC has been shown to reduce the expression of the enzyme Mono Amine Oxidase (MAO), which is responsible for the metabolism of monoamines. MC treatment reduces levels of plasma corticosterone and restores hippocampal BDNF (full form) protein in stressed animals. Further, MC has shown its protective effect against amyloid-beta, MPTP, rotenone, 6-OHDA, etc. suggesting its potential role against neurodegenerative disorders. The aim of the present review is to highlight the therapeutic potential of MC in the treatment of several neurological, neuropsychiatric, and neurodegenerative disorders.

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杨梅素在治疗神经、神经精神和神经退行性疾病方面的治疗潜力。

杨梅素（MC），3,5,7,3',4',5'-六羟黄酮，化学上属于类黄酮，已知具有抗氧化、抗菌、抗糖尿病和神经保护作用。众所周知，MC 能抑制活性氧（ROS）、脂质过氧化（MDA）和炎症指标的生成。据报道，它能改善人脑和外周的胰岛素功能。此外，它还能调节多种神经化学物质，包括谷氨酸、GABA、5-羟色胺等。研究表明，MC 能减少负责单胺代谢的单胺氧化酶（MAO）的表达。MC 治疗可降低血浆皮质酮水平，恢复受压动物海马 BDNF（全形）蛋白。此外，MC 还对淀粉样蛋白-β、MPTP、鱼藤酮、6-OHDA 等具有保护作用，这表明它对神经退行性疾病具有潜在作用。本综述旨在强调 MC 在治疗多种神经、神经精神和神经退行性疾病方面的治疗潜力。

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来源期刊

CNS & neurological disorders drug targets 医学-神经科学

CiteScore

5.10

自引率

3.30%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Aims & Scope CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.