Predictive biomarkers for colorectal cancer: a state-of-the-art systematic review.

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-09-12 DOI:10.1080/1354750X.2023.2247185

Moeez Maqbool, Aden Khan, Areej Shahzad, Zouina Sarfraz, Azza Sarfraz, Hinna Aftab, Ali Jaan

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引用次数: 1

Abstract

Introduction: Colorectal cancer (CRC) poses a substantial health burden, with early detection paramount for improved prognosis. This study aims to evaluate potential CRC biomarkers and detection techniques.

Materials and methods: This systematic review, reported in adherence to PRISMA Statement 2020 guidelines, collates the latest research on potential biomarkers and detection/prognosis methods for CRC, spanning the last decade.

Results: Out of the 38 included studies, diverse biomarkers and detection methods emerged, with DNA methylation markers like SFRP2 and SDC2, microRNAs including miR-1290, miR-506, and miR-4316, and serum and plasma markers such as NTS levels and U2 snRNA fragments standing out. Methylated cfDNA and m5C methylation alteration in immune cells of the blood, along with circular RNA, showed promise as diagnostic markers. Meanwhile, techniques involving extracellular vesicles and lateral flow immunoassays exhibited potential for swift and effective CRC screening.

Discussion: Our state-of-the-art review identifies potential biomarkers, including SFRP2, SDC2, miR-1290, miR-506, miR-4316, and U2 snRNA fragments, with significant potential in enhancing CRC detection. However, comprehensive validation studies and a rigorous evaluation of clinical utility and cost-effectiveness remain necessary before integration into routine clinical practice.

Conclusion: The findings emphasize the need for continued research into biomarkers and detection methods to improve patient outcomes.

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结直肠癌癌症的预测生物标志物：一项最先进的系统综述。

简介：癌症结直肠癌（CRC）造成了巨大的健康负担，早期发现对改善预后至关重要。本研究旨在评估潜在的CRC生物标志物和检测技术。材料和方法：根据PRISMA Statement 2020指南报告的这项系统综述，整理了过去十年中对CRC潜在生物标志物和检测/预后方法的最新研究。结果：在38项纳入的研究中，出现了不同的生物标志物和检测方法，其中DNA甲基化标记物如SFRP2和SDC2，微小RNA包括miR-1290、miR-506和miR-4316，血清和血浆标记物如NTS水平和U2 snRNA片段脱颖而出。血液免疫细胞中的甲基化cfDNA和m5C甲基化改变，以及环状RNA，显示出作为诊断标志物的前景。同时，涉及细胞外小泡和侧流免疫测定的技术显示出快速有效筛查CRC的潜力。讨论：我们最新的综述确定了潜在的生物标志物，包括SFRP2、SDC2、miR-1290、miR-506、miR-4316和U2 snRNA片段，在增强CRC检测方面具有显著潜力。然而，在纳入常规临床实践之前，全面的验证研究和对临床效用和成本效益的严格评估仍然是必要的。结论：研究结果强调了继续研究生物标志物和检测方法以改善患者预后的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.