Effects of Helicobacter pylori Infection on the Prognosis of Chronic Atrophic Gastritis by Inducing the Macrophage Polarization.

IF 1.4 Q4 GASTROENTEROLOGY & HEPATOLOGY Gastroenterology Research Pub Date : 2023-08-01 DOI:10.14740/gr1636
Chun Na Zhao, Li Li Xiao, Ying Zhang
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Abstract

Background: Recently, the effects of Helicobacter pylori (H. pylori) infection on the prognosis of chronic atrophic gastritis (CAG) are still unclear. The aim of our study was to discuss the role of H. pylori infection on the prognosis of CAG by inducing the M1/M2 macrophage polarization.

Methods: A total of 180 subjects as control (group 1), CAG patients without H. pylori infection (group 2) and H. pylori-associated CAG patients (group 3) were respectively recruited for this cross-sectional investigation in Daqing Oilfield General Hospital from May 2019 to July 2020. Their serum samples were collected to determine the concentrations of pro-inflammatory and anti-inflammatory cytokines. Meanwhile, the gastric mucosa was excised to determine the related gene expressions on the M1/M2 macrophage polarization. Then the prognosis of CAG was evaluated according to the status of clinical manifestations and endoscopic examination after the follow-up.

Results: Notably, it was proved that compared with the control group, the expressions and concentrations of pro-inflammatory cytokines (M1 macrophage: inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and interleukin-6 (IL-6)) were significantly higher, while the anti-inflammatory cytokines (M2 macrophage: arginase-1 (Arg-1), IL-4 and IL-10) were apparently reduced in the group 2 and group 3 (P < 0.05). Moreover, more days were needed for the prognosis of CAG in group 3 than those in group 2, which was accompanied by higher expressions of pro-inflammatory and lower anti-inflammatory cytokines at the baseline (P < 0.05). Furthermore, negative correlations were shown between the concentrations of iNOS, TNF-α, IFN-γ and IL-6, and the prognosis of CAG (P < 0.05), while positive correlations were observed between the contents of IL-4 and IL-10, and prognosis of CAG (P < 0.05).

Conclusion: These above results indicated that H. pylori infection-induced disorders of M1/M2 macrophage polarization could affect the prognosis of CAG.

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幽门螺杆菌感染诱导巨噬细胞极化对慢性萎缩性胃炎预后的影响。
背景:目前,幽门螺杆菌(h.p ylori)感染对慢性萎缩性胃炎(CAG)预后的影响尚不清楚。本研究旨在探讨幽门螺杆菌感染通过诱导M1/M2巨噬细胞极化对CAG预后的影响。方法:选取2019年5月至2020年7月大庆油田总医院CAG患者180例,分别为对照组(1组)、未感染幽门螺杆菌CAG患者(2组)和幽门螺杆菌相关CAG患者(3组)。收集他们的血清样本,测定促炎和抗炎细胞因子的浓度。同时,切除胃黏膜,检测巨噬细胞M1/M2极化的相关基因表达。随访后根据临床表现及内镜检查情况评价CAG的预后。结果:值得注意的是,与对照组相比,2组和3组促炎因子(M1巨噬细胞:诱导型一氧化氮合酶(iNOS)、肿瘤坏死因子-α (TNF-α)、干扰素-γ (IFN-γ)、白细胞介素-6 (IL-6))的表达和浓度显著升高,抗炎因子(M2巨噬细胞:精氨酸酶-1 (Arg-1)、IL-4、IL-10)的表达和浓度明显降低(P < 0.05)。3组CAG预后所需天数较2组延长,且促炎细胞因子在基线水平上表达升高,抗炎细胞因子在基线水平上表达降低(P < 0.05)。iNOS、TNF-α、IFN-γ、IL-6浓度与CAG预后呈负相关(P < 0.05), IL-4、IL-10含量与CAG预后呈正相关(P < 0.05)。结论:幽门螺杆菌感染引起的M1/M2巨噬细胞极化紊乱可影响CAG的预后。
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来源期刊
Gastroenterology Research
Gastroenterology Research GASTROENTEROLOGY & HEPATOLOGY-
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发文量
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