Transfusion-Related Acute Lung Injury Caused by HLA-II Antibodies: A Case Report.

Laboratory medicine Pub Date : 2023-09-05 DOI:10.1093/labmed/lmac145

Xinxin Hao, Jue Wang, Tiegang Li, Qiushi Wang

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Abstract

Objective: The aim of this study was to retrospectively analyze the etiology of a case of suspected transfusion-related acute lung injury (TRALI) occurring after blood transfusion.

Methods: The clinical symptoms, signs, imaging examinations, and laboratory test results of a patient with suspected TRALI after blood transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) genotyping of the patient and HLA antibodies of the plasma donors were performed.

Results: The clinical manifestations of the patient were consistent with those of TRALI after blood transfusion. This TRALI was treated by timely ventilator support. The patient results of high-resolution HLA genotyping were HLA-A* 01:01, 11:01; HLA-B* 15:02, 37:01; HLA-C* 06:02, 08:01; DRB1* 10:01, 12:02; DRB3* 03:01, 03:01; DQA1* 01:05, 06:01; DQB1* 03:01, 05:01; DPA1* 01:03, 02:01; and DPB1* 02:01, 09:01. Of the 6 plasma donors tested, 3 were found to have HLA-II antibodies, which were HLA-DPA1*01:03, HLA-DQB1*03:01, and HLA-DQB1*03:01 antibodies.

Conclusion: We described a case of TRALI caused by HLA-DQB1*03:01 antibody and DPA1*01:03 antibody.

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HLA-II抗体引起的输血相关急性肺损伤1例报告。

目的:回顾性分析1例输血后疑似输血相关性急性肺损伤(TRALI)的病因。方法:回顾性分析1例疑似TRALI患者输血后的临床症状、体征、影像学检查及实验室检查结果，并对患者进行人白细胞抗原(HLA)基因分型及血浆供者HLA抗体检测。结果:患者输血后的临床表现与TRALI一致。及时给予呼吸机支持治疗TRALI。患者高分辨率HLA基因分型结果为HLA- a * 01:01, 11:01;Hla-b * 15:02, 37:01;Hla-c * 06:02, 08:01;Drb1 * 10:01, 12:02;dr * 03:01, 03:01;Dqa1 * 01:05, 06:01;Dqb1 * 03:01, 05:01;Dpa1 * 01:03, 02:01;DPB1* 02:01, 09:01。6例血浆供者中，3例检测出HLA-II抗体，分别为HLA-DPA1*01:03、HLA-DQB1*03:01和HLA-DQB1*03:01抗体。结论:我们报道了1例HLA-DQB1*03:01抗体和DPA1*01:03抗体引起的TRALI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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