[Adipomyokines in children with obesity].

Q4 Medicine Problemy endokrinologii Pub Date : 2023-08-30 DOI:10.14341/probl13250
Yu V Burmitskaya, O V Vasyukova, P L Okorokov, Z T Zuraeva, O B Bezlepkina
{"title":"[Adipomyokines in children with obesity].","authors":"Yu V Burmitskaya,&nbsp;O V Vasyukova,&nbsp;P L Okorokov,&nbsp;Z T Zuraeva,&nbsp;O B Bezlepkina","doi":"10.14341/probl13250","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adipomyokines are synthesized and secreted into the bloodstream by cells of both muscle and adipose tissue. They can have both a negative metabolic effect, acting as pro-inflammatory adipokines in obesity, and a positive one, increasing in response to physical exertion in the form of myokines.</p><p><strong>Aim: </strong>To study the features of adipocytokine secretion in children with constitutionally exogenous obesity.</p><p><strong>Materials and methods: </strong>The study included 80 patients: 60 adolescents aged 15 [13; 16] years with constitutionally exogenous obesity SDS BMI: 3.0 [2.6; 3.3] and 20 control group children aged 16 [15; 17] years without excess weight SDS BMI: -0.3 [-1.25; 0.33]. Commercial enzyme immunoassay kits were used to determine the level of adipomyokines. The compositional composition of the body was evaluated by bioimpedance analysis (InBody 770 analyzer, South Korea) in the morning, on an empty stomach. Statistical processing was carried out using STATISTICA v.12.0 (StatSoft Inc., USA). The results are presented in the form of median (Me) and quartiles (Q1; Q3) corresponding to 25 and 75 percentiles. The critical significance level (p) was assumed to be &lt;0.05.</p><p><strong>Results: </strong>Levels of IL-6 and irisin are statistically significantly higher in obese adolescents compared to the control group: 0.55 [0.226; 1.35] pg/ml vs 0.202 [0.128; 0.652] pg/ml (p=0.041) and 11.16 [6.6; 22.76] mcg/ml vs 7.36 [6.48; 9.68] mcg/ml (p=0.043), respectively. Concentrations of IL-6, myostatin and decorin increase with an increase in the degree of obesity: grade I vs III: 0.226 [0.224; 0.398] vs 0.80 [0.36; 1.81] pg/ml (p=0,0197), 25,85 [21,53; 28,23] vs 31.41 [24.36; 35.06] ng/ml (p=0.03), 4065.3 [3244.9; 5245.5] vs 5322.5 [4199.8; 7702.4] pg/ml (p=0.0376), respectively. In obese children, IL-6 levels positively correlate with BMI, SDS BMI and the amount of adipose tissue, and myostatin - with BMI and SDS BMI. The concentration of irisin in the blood serum is significantly higher in obese girls than in obese boys and healthy girls. Obese patients, compared with lean peers, are characterized by a statistically significantly higher content of both fat and lean mass. With the progression of obesity, there is a statistically significant increase in the ratio of fat to lean mass (I degree - 0.66 [0.56; 0.7], III - 0.78 [0.68; 0.98] (p=0.0073).</p><p><strong>Conclusion: </strong>Patients with obesity and normal body weight have different levels of adipomyokines. An increase in the level of IL-6 with the progression of obesity is directly related to an increase in the content of adipose tissue. Further study of the features of adipocytokine secretion, their relationship with the features of the body composition and metabolic complications in obesity is required.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520902/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problemy endokrinologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14341/probl13250","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1

Abstract

Background: Adipomyokines are synthesized and secreted into the bloodstream by cells of both muscle and adipose tissue. They can have both a negative metabolic effect, acting as pro-inflammatory adipokines in obesity, and a positive one, increasing in response to physical exertion in the form of myokines.

Aim: To study the features of adipocytokine secretion in children with constitutionally exogenous obesity.

Materials and methods: The study included 80 patients: 60 adolescents aged 15 [13; 16] years with constitutionally exogenous obesity SDS BMI: 3.0 [2.6; 3.3] and 20 control group children aged 16 [15; 17] years without excess weight SDS BMI: -0.3 [-1.25; 0.33]. Commercial enzyme immunoassay kits were used to determine the level of adipomyokines. The compositional composition of the body was evaluated by bioimpedance analysis (InBody 770 analyzer, South Korea) in the morning, on an empty stomach. Statistical processing was carried out using STATISTICA v.12.0 (StatSoft Inc., USA). The results are presented in the form of median (Me) and quartiles (Q1; Q3) corresponding to 25 and 75 percentiles. The critical significance level (p) was assumed to be <0.05.

Results: Levels of IL-6 and irisin are statistically significantly higher in obese adolescents compared to the control group: 0.55 [0.226; 1.35] pg/ml vs 0.202 [0.128; 0.652] pg/ml (p=0.041) and 11.16 [6.6; 22.76] mcg/ml vs 7.36 [6.48; 9.68] mcg/ml (p=0.043), respectively. Concentrations of IL-6, myostatin and decorin increase with an increase in the degree of obesity: grade I vs III: 0.226 [0.224; 0.398] vs 0.80 [0.36; 1.81] pg/ml (p=0,0197), 25,85 [21,53; 28,23] vs 31.41 [24.36; 35.06] ng/ml (p=0.03), 4065.3 [3244.9; 5245.5] vs 5322.5 [4199.8; 7702.4] pg/ml (p=0.0376), respectively. In obese children, IL-6 levels positively correlate with BMI, SDS BMI and the amount of adipose tissue, and myostatin - with BMI and SDS BMI. The concentration of irisin in the blood serum is significantly higher in obese girls than in obese boys and healthy girls. Obese patients, compared with lean peers, are characterized by a statistically significantly higher content of both fat and lean mass. With the progression of obesity, there is a statistically significant increase in the ratio of fat to lean mass (I degree - 0.66 [0.56; 0.7], III - 0.78 [0.68; 0.98] (p=0.0073).

Conclusion: Patients with obesity and normal body weight have different levels of adipomyokines. An increase in the level of IL-6 with the progression of obesity is directly related to an increase in the content of adipose tissue. Further study of the features of adipocytokine secretion, their relationship with the features of the body composition and metabolic complications in obesity is required.

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[肥胖儿童中的脂肪酸]。
背景:脂肪酸是由肌肉和脂肪组织的细胞合成并分泌到血液中的。它们既有负代谢作用,在肥胖中起到促炎性脂肪因子的作用,也有正代谢作用,以肌细胞因子的形式增加对体力消耗的反应。目的:研究先天性外源性肥胖儿童脂肪细胞因子分泌的特点。材料和方法:该研究包括80名患者:60名15岁[13;16岁的青少年,具有宪法外源性肥胖SDS BMI:3.0[2.6;3.3]和20名16岁[15;17岁的对照组儿童,没有超重SDS BMI:-0.3[1.25;0.33]。使用商业酶免疫测定试剂盒测定脂肪肌因子水平。早上空腹通过生物阻抗分析(InBody 770分析仪,韩国)评估身体的成分组成。使用STATISTICAv.12.0(StatSoft股份有限公司,美国)进行统计处理。结果以中位数(Me)和四分位数(Q1;Q3)的形式表示,分别对应25和75个百分点。临界显著性水平(p)被假定为<;结果:与对照组相比,肥胖青少年的IL-6和鸢尾素水平在统计学上显著升高:分别为0.55[0.226;1.35]pg/ml vs 0.202[0.128;0.652]pg/ml(p=0.041)和11.16[6.6;22.76]mcg/ml vs 7.36[6.48;9.68]mcg/ml(p=0.043)。IL-6、肌生长抑制素和花色苷的浓度随着肥胖程度的增加而增加:I级与III级:分别为0.226[0.224;0.398]vs 0.80[0.36;1.81]pg/ml(p=0.0197)、25,85[21,53;28,23]vs 31.41[24.36;35.06]ng/ml(p=0.03)、4065.3[3244.9;5245.5]vs 5322.5[419.98;7702.4]pg/ml(p=0.0376)。在肥胖儿童中,IL-6水平与BMI、SDS BMI和脂肪组织量呈正相关,肌生长抑制素与BMI和SDS BMI呈正相关。肥胖女孩血清中鸢尾素的浓度明显高于肥胖男孩和健康女孩。肥胖患者与瘦同龄人相比,其特征是脂肪和瘦物质的含量在统计学上显著较高。随着肥胖的发展,脂肪与瘦的比例在统计学上显著增加(I度-0.66[0.56;0.7],III度-0.78[0.68;0.98](p=0.0073)。结论:肥胖和正常体重患者的脂肪肌因子水平不同。IL-6水平随着肥胖的进展而增加与脂肪组织含量的增加直接相关。需要进一步研究肥胖患者脂肪细胞因子分泌的特征及其与身体成分和代谢并发症特征的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
期刊最新文献
[Сhronic autoimmune thyroiditis is a «signal disease» in the multiorgan autoimmune syndrome]. [Impact of surgical treatment of morbid obesity on joint diseases]. [Metastatic lesions of the adrenal glands. The experience of Endocrinology Research Center.] [An integrated approach to the treatment of pretibial myxedema based on pulse therapy with prednisolone and electrical neuromyostimulation (FREMS-therapy) in a patient with Graves' disease and thyroid eye disease]. [Legal issues of the use of continuous glucose monitoring in children with type 1 diabetes].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1