Towards an adiposity-related disease framework for the diagnosis and management of obesities.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2023-10-01 Epub Date: 2023-05-10 DOI:10.1007/s11154-023-09797-2
Carolina M Perdomo, Icíar Avilés-Olmos, Dror Dicker, Gema Frühbeck
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引用次数: 3

Abstract

Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, among others. People living with obesity need a diagnostic approach that considers an exhaustive pathophysiology and complications assessment. Thus, it is essential to warrant a holistic diagnosis and management that guarantees an adequate health status, and quality of life. The present review summarizes the different complications associated with obesity, at the same time, we aim to fostering a novel framework that enhances a patient-centered approach to obesity management in the precision medicine era.

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肥胖相关疾病的诊断和管理框架。
肥胖是一种复杂的疾病,经常复发,并伴有多种并发症,由于其发病率不断上升,并与许多并发症(包括代谢障碍、机械病理和癌症等)相关,因此成为世界卫生的重中之重。值得注意的是,过度肥胖伴随着慢性炎症、氧化应激、胰岛素抵抗和随后的器官功能障碍。这种功能失调的脂肪组织最初储存在内脏库中,随后溢出,在肝脏、心脏、肌肉和胰腺等异位库中产生脂毒性。肥胖患者需要一种全面的病理生理学和并发症评估的诊断方法。因此,必须保证全面的诊断和管理,以确保适当的健康状况和生活质量。本综述总结了与肥胖相关的不同并发症,同时,我们旨在建立一个新的框架,在精准医学时代加强以患者为中心的肥胖管理方法。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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