Genome-wide by environment interaction studies of maternal smoking and educational score in UK biobank.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY Psychiatric Genetics Pub Date : 2023-08-01 DOI:10.1097/YPG.0000000000000347

Huimei Huang, Li Liu, Fenling Feng, Hongli Sun, Fei Li, Haibin Wu, Chujun Liang, Xiaomeng Chu, Yujie Ning, Feng Zhang

{"title":"Genome-wide by environment interaction studies of maternal smoking and educational score in UK biobank.","authors":"Huimei Huang, Li Liu, Fenling Feng, Hongli Sun, Fei Li, Haibin Wu, Chujun Liang, Xiaomeng Chu, Yujie Ning, Feng Zhang","doi":"10.1097/YPG.0000000000000347","DOIUrl":null,"url":null,"abstract":"Purpose: This study aimed to investigate the associations between maternal smoking (MS) and education score in adult offspring.Methods: To better understand this link, we performed a two-stage genome-wide by environment interaction studies (GWEIS) of MS and offspring education score in UK Biobank cohort. Specifically, 276 996 subjects from England were enrolled in the discovery study, while 24 355 subjects from Scotland and 14 526 subjects from Wales were enrolled in the replication study. GWEIS were conducted by PLINK 2.0 with MS used as an environmental risk factor.Results: Significant GWEIS associations ( P < 0.0001) between MS and offspring education score in both the discovery cohort and two replicate cohorts (Scotland population and Wales population) were identified. GWEIS identified 2 independent significant single nucleotide polymorphism-MS interaction, with one variant located in the chromosomal 16 (rs72768988, Position: 22,768,798, P = 1.22 × 10 -8 , β = 6.7662) and the other one located in 2q32.3 region (2 : 196424612_GT_G, Position: 196 424 612, 3.60 × 10 -9 , β = -0.4721).Conclusion: Our results suggested 2q32.3 region and HECW2 gene could negatively moderate the influence of MS on offspring's educational status.","PeriodicalId":20734,"journal":{"name":"Psychiatric Genetics","volume":"33 4","pages":"152-159"},"PeriodicalIF":1.5000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/7f/pg-33-152.PMC10325563.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatric Genetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/YPG.0000000000000347","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aimed to investigate the associations between maternal smoking (MS) and education score in adult offspring.

Methods: To better understand this link, we performed a two-stage genome-wide by environment interaction studies (GWEIS) of MS and offspring education score in UK Biobank cohort. Specifically, 276 996 subjects from England were enrolled in the discovery study, while 24 355 subjects from Scotland and 14 526 subjects from Wales were enrolled in the replication study. GWEIS were conducted by PLINK 2.0 with MS used as an environmental risk factor.

Results: Significant GWEIS associations ( P < 0.0001) between MS and offspring education score in both the discovery cohort and two replicate cohorts (Scotland population and Wales population) were identified. GWEIS identified 2 independent significant single nucleotide polymorphism-MS interaction, with one variant located in the chromosomal 16 (rs72768988, Position: 22,768,798, P = 1.22 × 10 -8 , β = 6.7662) and the other one located in 2q32.3 region (2 : 196424612_GT_G, Position: 196 424 612, 3.60 × 10 -9 , β = -0.4721).

Conclusion: Our results suggested 2q32.3 region and HECW2 gene could negatively moderate the influence of MS on offspring's educational status.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

英国生物银行中母亲吸烟与教育程度的全基因组环境相互作用研究。

目的:本研究旨在探讨母亲吸烟(MS)与成年子女教育评分的关系。方法:为了更好地理解这种联系，我们在英国生物银行队列中对MS和后代教育评分进行了两阶段全基因组环境相互作用研究(GWEIS)。具体来说，来自英格兰的276 996名受试者被纳入了发现研究，来自苏格兰的24 355名受试者和来自威尔士的14 526名受试者被纳入了重复研究。GWEIS采用PLINK 2.0进行，MS作为环境风险因子。结论:我们的研究结果提示2q32.3区域和HECW2基因可以负向调节MS对子代教育状况的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.