Depression and sarcopenia: a Mendelian randomization analysis.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY Psychiatric Genetics Pub Date : 2023-08-01 DOI:10.1097/YPG.0000000000000346

Yehong Lu, Ruijie Zhang, Qiang Zheng

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Abstract

Background: The association between depression and sarcopenia has been reported in observational studies but the causality of depression on sarcopenia remained unknown. We aimed to assess the causal effect between major depressive disorder (MDD) and sarcopenia using the two-sample Mendelian randomization (MR) method.

Methods: A set of genetics instruments were used for analysis, derived from publicly available genetic summary data. Clinically, appendicular lean mass (ALM) and low hand grip strength (LHGS) have been widely used for the diagnosis of sarcopenia. Inverse-variance weighted method, weighted median method, MR-Egger, MR Pleiotropy RESidual Sum and Outlier test were used for the bidirectional MR analyses.

Results: No evidence for an effect of MDD on sarcopenia risk was found. MDD was not associated with ALM [effect = -0.17 (-0.60 to 0.27), P = 0.449] and LHGS [effect = 0.24 (-0.46 to 0.93), P = 0.506]. Sarcopenia was not associated with MDD [ALM: odds ratio (OR) = 0.999 (0.996-1.001), P = 0.374; LHGS: OR = 0.999 (0.996-1.002), P = 0.556].

Conclusion: MDD and Sarcopenia might mutually have no causal effect on each other.

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抑郁症和肌肉减少症:孟德尔随机分析。

背景:观察性研究已经报道了抑郁症和肌肉减少症之间的关系，但抑郁症与肌肉减少症的因果关系尚不清楚。我们的目的是利用双样本孟德尔随机化(MR)方法来评估重度抑郁症(MDD)和肌肉减少症之间的因果关系。方法:利用公开的遗传汇总资料，采用一套遗传学仪器进行分析。临床上，阑尾瘦质量(ALM)和低握力(LHGS)被广泛用于肌肉减少症的诊断。双向MR分析采用反方差加权法、加权中位数法、MR- egger法、MR多效残差和和离群检验。结果:没有证据表明重度抑郁症对肌肉减少症的风险有影响。MDD与ALM [effect = -0.17 (-0.60 ~ 0.27)， P = 0.449]和LHGS [effect = 0.24 (-0.46 ~ 0.93)， P = 0.506]无关。肌少症与MDD无相关性[ALM:比值比(OR) = 0.999 (0.996-1.001)， P = 0.374;Lhgs: or = 0.999 (0.996-1.002)， p = 0.556]。结论:重度抑郁症与肌肉减少症之间可能没有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.