Yakov A Osipov, Olga V Posukh, Darya A Kalashnikova, Polina A Antoshina, Petr P Laktionov, Polina A Skrypnik, Stepan N Belyakin, Prim B Singh
{"title":"H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos.","authors":"Yakov A Osipov, Olga V Posukh, Darya A Kalashnikova, Polina A Antoshina, Petr P Laktionov, Polina A Skrypnik, Stepan N Belyakin, Prim B Singh","doi":"10.1007/s00412-023-00809-3","DOIUrl":null,"url":null,"abstract":"<p><p>Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone methyl transferases (HMTases) in regulating heterochromatinization of the imprinted paternal chromosomal set in male embryos. We found that H3K9 and H420 HMTases are required for heterochromatinization of the paternal chromosomes. We present evidence that both HMTases maintain the paternal \"imprint\" during the cleavage divisions when both parental chromosome sets are euchromatic. A testable model that accommodates our findings is proposed.</p>","PeriodicalId":10248,"journal":{"name":"Chromosoma","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chromosoma","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00412-023-00809-3","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone methyl transferases (HMTases) in regulating heterochromatinization of the imprinted paternal chromosomal set in male embryos. We found that H3K9 and H420 HMTases are required for heterochromatinization of the paternal chromosomes. We present evidence that both HMTases maintain the paternal "imprint" during the cleavage divisions when both parental chromosome sets are euchromatic. A testable model that accommodates our findings is proposed.
期刊介绍：
Chromosoma publishes research and review articles on the functional organization of the eukaryotic cell nucleus, with a particular emphasis on the structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis; the function and dynamics of subnuclear compartments; the nuclear envelope and nucleocytoplasmic interactions, and more.
The scope of Chromosoma encompasses genetic, biophysical, molecular and cell biological studies.
Average time from receipt of contributions to first decision: 22 days
Publishes research and review articles on the functional organization of the eukaryotic cell nucleus
Topics include structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis and more
Encompasses genetic, biophysical, molecular and cell biological studies.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
