Plasma proteins as potential biomarkers of aging of single tissue and cell type.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-14 DOI:10.1007/s10522-023-10065-8
Daigo Okada
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Abstract

Plasma proteins serve as biomarkers of aging and various age-related diseases. While a number of plasma proteins have been identified that increase or decrease with age, the interpretation of each protein is challenging. This is due to the nature of plasma, which is a mixture of factors secreted by many different tissues and cells. Therefore, the catalog of age-related proteins secreted by a single cell type in a single tissue would be useful for understanding tissue-specific aging patterns. In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male testis (Leydig cells), KLK3 and KLK4 in the male prostate (glandular cells), MPO and ACP5 in immune cells. This list of proteins would be potentially useful for understanding age-related changes in the plasma proteome and inter-tissue networks.

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血浆蛋白作为单一组织和细胞类型衰老的潜在生物标志物。
血浆蛋白是衰老和各种老年相关疾病的生物标志物。虽然已经确定了一些血浆蛋白会随着年龄的增长而增加或减少,但对每种蛋白的解释都具有挑战性。这是由于血浆的性质决定的,它是由许多不同组织和细胞分泌的因子混合而成的。因此,单个组织中单个细胞类型分泌的与年龄相关的蛋白质目录将有助于了解组织特异性衰老模式。在本研究中,作者通过对人类蛋白质图谱和最近发表的大规模衰老蛋白质组学研究成果进行综合数据挖掘,解决了这一难题。最后,我们确定了由单一组织和单一细胞类型产生的 17 种与衰老相关的蛋白质:肝脏(肝细胞)中的 MBL2 和 HP,肺脏(II 型肺泡细胞)中的 SFTPC,垂体(前体细胞)中的 PRL 和 POMC,胰腺(胰腺细胞)中的 GCG、CUZD1 和 CPA2,骨骼肌(肌细胞)中的 MYBPC1、甲状旁腺(腺细胞)中的 PTH,唾液腺(腺细胞)中的 LPO 和 AMY1A,男性睾丸(莱氏细胞)中的 INSL3,男性前列腺(腺细胞)中的 KLK3 和 KLK4,免疫细胞中的 MPO 和 ACP5。这些蛋白质可能有助于了解血浆蛋白质组和组织间网络中与年龄有关的变化。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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