How to plan and manage an individual participant data meta-analysis. An illustrative toolkit

IF 5 2区 生物学 Q1 MATHEMATICAL & COMPUTATIONAL BIOLOGY Research Synthesis Methods Pub Date : 2023-09-12 DOI:10.1002/jrsm.1670
Lauren Maxwell, Priya Shreedhar, Mabel Carabali, Brooke Levis
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Abstract

Individual participant data meta-analyses (IPD-MAs) have several benefits over standard aggregate data meta-analyses, including the consideration of additional participants, follow-up time, and the joint consideration of study- and participant-level heterogeneity for improved diagnostic and prognostic model development and evaluation. However, IPD-MAs are resource-intensive and require careful budgeting of time from data contributing groups, a dedicated management team, diversity of expertise, clearly documented data sharing and authorship agreements, and consistent and clear communication. We present a toolkit to facilitate the implementation and management of IPD-MAs, from study recruitment to retrospective harmonization. The toolkit was developed and refined over our work on multiple multinational IPD-MA projects over the last 13 years. The toolkit's budget and email templates, agreements, project management spreadsheets, and standard operating procedures are meant to facilitate routine IPD-MA tasks to expedite implementing and managing future IPD-MA projects.

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如何规划和管理个体参与者数据荟萃分析。一个说明性的工具包。
个体参与者数据荟萃分析(IPD MA)比标准汇总数据荟萃分析有几个好处,包括考虑额外的参与者、随访时间,以及联合考虑研究和参与者水平的异质性,以改进诊断和预后模型的开发和评估。然而,IPD MAs是资源密集型的,需要数据贡献小组、专门的管理团队、专业知识的多样性、明确记录的数据共享和作者协议以及一致清晰的沟通来仔细预算时间。我们提供了一个工具包,以促进IPD MA的实施和管理,从研究招募到回顾性协调。该工具包是在我们过去13年在多个跨国IPD-MA项目上的工作中开发和完善的 年。该工具包的预算和电子邮件模板、协议、项目管理电子表格和标准操作程序旨在促进IPD-MA的日常任务,以加快未来IPD-MA项目的实施和管理。
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来源期刊
Research Synthesis Methods
Research Synthesis Methods MATHEMATICAL & COMPUTATIONAL BIOLOGYMULTID-MULTIDISCIPLINARY SCIENCES
CiteScore
16.90
自引率
3.10%
发文量
75
期刊介绍: Research Synthesis Methods is a reputable, peer-reviewed journal that focuses on the development and dissemination of methods for conducting systematic research synthesis. Our aim is to advance the knowledge and application of research synthesis methods across various disciplines. Our journal provides a platform for the exchange of ideas and knowledge related to designing, conducting, analyzing, interpreting, reporting, and applying research synthesis. While research synthesis is commonly practiced in the health and social sciences, our journal also welcomes contributions from other fields to enrich the methodologies employed in research synthesis across scientific disciplines. By bridging different disciplines, we aim to foster collaboration and cross-fertilization of ideas, ultimately enhancing the quality and effectiveness of research synthesis methods. Whether you are a researcher, practitioner, or stakeholder involved in research synthesis, our journal strives to offer valuable insights and practical guidance for your work.
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