The association between comorbidities and disease activity in spondyloarthritis – A narrative review

IF 4.5 2区医学 Q1 RHEUMATOLOGY Best Practice & Research in Clinical Rheumatology Pub Date : 2023-09-01 DOI:10.1016/j.berh.2023.101857

Philipp Bosch , Sizheng Steven Zhao , Elena Nikiphorou

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Abstract

Comorbidities, including cardiovascular disease, osteoporosis, and depression, are more prevalent in patients with spondyloarthritis (SpA) than in the general population. Clinical and laboratory markers of disease activity are associated with numerous of these comorbidities, and studies suggest that the treatment of SpA can have a positive impact on comorbidities; conversely, managing comorbidities can improve disease activity. Therefore, the screening of comorbidities is considered a core component of a rheumatology consultation, and treatment should be performed in liaison with other health professionals (e.g. general physicians). Validated tools and questionnaires can be used for not only the detection but also the monitoring of potential comorbidities. Understanding whether a comorbidity is a separate disease entity, linked to SpA or its treatment, or an extra-musculoskeletal manifestation of the disease is important to identify the most appropriate treatment options.

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脊柱关节炎合并症与疾病活动性之间的关系--叙述性综述

脊柱关节炎（SpA）患者的合并症（包括心血管疾病、骨质疏松症和抑郁症）比一般人群更为普遍。疾病活动性的临床和实验室指标与许多合并症相关，研究表明，SpA 的治疗可对合并症产生积极影响；反之，控制合并症可改善疾病活动性。因此，筛查合并症被认为是风湿病学会诊的核心内容，治疗时应与其他医疗专业人员（如普通内科医生）保持联系。经过验证的工具和问卷不仅可用于检测，还可用于监测潜在的合并症。了解合并症是一种独立的疾病实体，与SpA或其治疗有关，还是一种疾病的肌肉骨骼外表现，对于确定最合适的治疗方案非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.