Donor-derived infections in solid organ transplant recipients.

IF 1.8 4区医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2023-10-01 Epub Date: 2023-08-08 DOI:10.1097/MOT.0000000000001094

Maddalena Peghin, Paolo Antonio Grossi

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引用次数: 1

Abstract

Purpose of review: The potential for transmission of donor-derived infections (DDIs) is impossible to eliminate, but a thoughtful and systematic approach to donor evaluation can mitigate the risk. Prevention is a key issue and clinicians must maintain a high index of suspicion and remain vigilant in staying up to date on emerging infections. COVID-19 and Monkeypox have represented a new challenge for infectious disease screening and recommendations have been evolving, as knowledge in the field has grown. Additional considerations for pretransplant deceased donor screening include testing for neglected and endemic infectious diseases such as strongyloidiasis and HTLV 1/2. Molecular diagnostic tests have improved awareness on pathogenicity of mollicutes and fungi in the setting of DDIs. The aim of this review is to provide an update on the most recent literature on DDI with a special focus on these emerging hot topics.

Recent findings: Donor screening for uncommon pathogens must be guided by knowledge of changing epidemiology of infectious disease and availability of new diagnostic methods.

Summary: Appropriate screening, early recognition, timely reporting, close monitoring, and appropriate management are essential to help reducing the risk of emerging DDIs.

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实体器官移植受者的供体源性感染。

综述目的：捐赠者来源感染（DDI）的传播潜力是不可能消除的，但对捐赠者进行深思熟虑和系统的评估可以降低风险。预防是一个关键问题，临床医生必须保持高度怀疑，并保持警惕，及时了解新出现的感染情况。新冠肺炎和猴痘对传染病筛查提出了新的挑战，随着该领域知识的增长，建议也在不断发展。移植前已故捐赠者筛查的其他考虑因素包括检测被忽视的地方性传染病，如强直性脊柱炎和HTLV 1/2。分子诊断测试提高了人们在DDI环境中对翅果属和真菌致病性的认识。这篇综述的目的是提供关于DDI的最新文献的更新，特别关注这些新兴的热点话题。最近的发现：捐赠者对罕见病原体的筛查必须以不断变化的传染病流行病学知识和新诊断方法的可用性为指导。总结：适当的筛查、早期识别、及时报告、密切监测和适当的管理对于帮助降低新出现DDI的风险至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.

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