Targeting host calcium channels and viroporins: a promising strategy for SARS-CoV-2 therapy.

IF 2.1 4区 医学 Q3 VIROLOGY Future Virology Pub Date : 2023-08-01 DOI:10.2217/fvl-2022-0203
Mona Fani, Maryam Moossavi, Hasan Bakhshi, Abozar Nasiri Jahrodi, Mohammad Reza Khazdair, Amir Hossein Zardast, Shokouh Ghafari
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Abstract

Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. Ca2+ is required to enhance the fusion process of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, some important inflammatory factors during SARS-CoV-2 infection are dependent on Ca2+ level. On the other hand, viroporins have emerged as attractive targets for antiviral therapy due to their essential role in viral replication and pathogenesis. By inhibiting the host calcium channels and viroporins, it is possible to limit the spread of infection. Therefore, calcium channel blockers (CCBs) and drugs targeting Viroporins can be considered an effective option in the fight against SARS-CoV-2.

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靶向宿主钙通道和病毒蛋白:一种有前途的SARS-CoV-2治疗策略
虽然已经度过了大流行阶段,但研究人员仍在研究各种药物。先前的证据表明,阻断钙通道可能是一种合适的治疗选择。Ca2+是增强严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)融合过程所必需的。此外,SARS-CoV-2感染过程中的一些重要炎症因子依赖于Ca2+水平。另一方面,由于病毒孔蛋白在病毒复制和发病机制中的重要作用,它们已成为抗病毒治疗的有吸引力的靶点。通过抑制宿主钙通道和病毒孔蛋白,可以限制感染的传播。因此,钙通道阻滞剂(CCBs)和靶向病毒蛋白的药物可以被认为是对抗SARS-CoV-2的有效选择。
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来源期刊
Future Virology
Future Virology 医学-病毒学
CiteScore
4.00
自引率
3.20%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.
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