Cross-shift change of acute kidney injury biomarkers in sugarcane farmers and cutters.

IF 3 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Human and Ecological Risk Assessment Pub Date : 2021-01-01 DOI:10.1080/10807039.2020.1812049
Ritthirong Pundee, Pornpimol Kongtip, Noppanun Nankongnab, Sirirat Anutrakulchai, Mark Gregory Robson, Susan Woskie
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引用次数: 5

Abstract

Sugarcane farmers and cutters have been reported to be at high risk of acute kidney injury. This cross-sectional study aimed to assess acute kidney injury biomarkers, and cross-shift change among 150 sugarcane cutters and 98 sugarcane farmers in Thailand. Physical health examination, environmental measurements, and measured urinary neutrophil gelatinase-associated lipocalin (NGAL) were assessed. Cross-shift change of urine creatinine (uCr), albumin creatinine ratio (ACR), and NGAL between sugarcane farmers and cutters was compared. Factors influencing abnormal post-shift ACR and NGAL were analyzed by binary logistic regression adjusted with covariates. Sugarcane cutters were significantly more likely to take nonsteroidal anti-inflammatory drugs (NSAID) and herbs to relieve pain than sugarcane farmers. Males were more likely to be current smokers and drinkers although 62% of cutters and 56% of farmers were female. Sugarcane farmers and cutters had similar post-shift estimated glomerular filtration rate (eGFR) and ACR levels. Cross-shift measurements showed that both sugarcane cutters and sugarcane farmers had significantly higher post-shift geometric mean (GM) urinary NGAL, but that the cross-shift changes of NGAL were significantly higher for sugarcane cutters (182%) vs. sugarcane farmers (112%). Water intake less than recommendation of subjects was a significant predictor of a higher risk for an abnormal post-shift ACR after controlling for covariates, while being a sugarcane cutter was a predictor of a lower risk of an abnormal risk of a post-shift NGAL after controlling for covariates. Measurements of heat stress (WBGT plus workload) found that sugarcane cutters exceeded recommended exposures while sugarcane farmers were compliance to the TLV. These findings suggest that to protect sugarcane farmers and cutters, preventative measures are needed.

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甘蔗种植户和切割机急性肾损伤生物标志物的交叉移位变化。
据报道,甘蔗种植者和收割者患急性肾损伤的风险很高。这项横断面研究旨在评估泰国150名甘蔗切割机和98名甘蔗农民的急性肾损伤生物标志物和交叉转移变化。评估身体健康检查、环境测量和尿中性粒细胞明胶酶相关脂钙蛋白(NGAL)测量。比较甘蔗种植户与切割机的尿肌酐(uCr)、白蛋白肌酐比值(ACR)和NGAL的交叉位移变化。采用经协变量校正的二元logistic回归分析影响轮班后异常ACR和NGAL的因素。甘蔗种植者比甘蔗种植者更有可能服用非甾体抗炎药(NSAID)和草药来缓解疼痛。男性更有可能是吸烟者和饮酒者,尽管62%的吸烟者和56%的农民是女性。甘蔗种植者和收割工人在轮班后估计肾小球滤过率(eGFR)和ACR水平相似。交叉位移测量结果显示,甘蔗切割机和甘蔗农民的尿液NGAL几何平均值(GM)均显著高于移位后,但NGAL的交叉位移变化甘蔗切割机(182%)明显高于甘蔗农民(112%)。在控制了协变量后,饮水量低于推荐量是班后ACR异常风险较高的显著预测因子,而在控制了协变量后,作为甘蔗切割工是班后NGAL异常风险较低的预测因子。热应力测量(WBGT加工作量)发现,甘蔗切割机超过了建议的暴露量,而甘蔗农民则遵守了TLV。这些发现表明,为了保护甘蔗种植者和收割者,需要采取预防措施。
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来源期刊
Human and Ecological Risk Assessment
Human and Ecological Risk Assessment 环境科学-环境科学
CiteScore
9.60
自引率
2.30%
发文量
68
审稿时长
2 months
期刊介绍: Human and Ecological Risk Assessment provides a resource for professionals researching and assessing environmental hazards to both humans and ecological systems. The editors expect papers published to be original, of sound science, purposeful for risk analysis (assessment, communication, management) and related areas, well written (in English), and a contribution to the scientific literature. The journal''s emphasis is on publication of papers that contribute to improvements in human and ecological health. The journal is an international, fully peer-reviewed publication that publishes eight issues annually. The journal''s scope includes scientific and technical information and critical analysis in the following areas: -Quantitative Risk Assessment- Comparative Risk Assessment- Integrated Human & Ecological Risk Assessment- Risk Assessment Applications to Human & Ecosystems Health- Exposure Assessment- Environmental Fate Assessment- Multi-Media Assessment- Hazard Assessment- Environmental Epidemiology- Statistical Models and Methods- Methods Development/Improvement- Toxicokinetics Modeling- Animal to Human Extrapolation- Risk Perception/Communication- Risk Management- Regulatory Issues
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