Clostridial prosthetic joint infections: A series of 16 cases and literature review

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES Infectious diseases now Pub Date : 2023-10-01 DOI:10.1016/j.idnow.2023.104776

L. Manceau , P. Bémer , J. Decroo , A. Jolivet-Gougeon , C. Plouzeau , M.-F. Lartigue , L. Bouard , R. Chenouard , C. Mazuet , A.-G. Leroy , the CRIOGO (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest) Study Team

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Abstract

Objectives

Prosthetic joint infections (PJIs) due to the Clostridium species have not been widely investigated. We aimed to characterize these uncommon infections.

Methods

We conducted a retrospective study between 2003 and 2020 in six French hospitals combined with a review of the literature.

Results

The main conclusions obtained from the 16 patients included were reinforced by the literature analysis: (i) Clostridium perfringens was the most frequently involved species, (ii) patients presented an advanced age at the time of prosthesis placement and infection, (iii) most of the infections were early- or delayed-onset, (iv) the prognosis for these PJIs remains poor, (v) when performed (n = 5), DAIR with 12-week antimicrobial therapy led to a favorable outcome in 80% of cases.

Conclusions

Given the low incidence of this infection, our work represents the largest series of clostridial PJIs reported to date and highlights some specificities of these infections. Further prospective studies are needed to confirm these results.

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梭菌性假体关节感染16例并文献复习

目的由梭菌引起的人工关节感染（PJIs）尚未得到广泛的研究。我们的目的是描述这些不常见的感染。方法2003年至2020年间，我们在法国的六家医院进行了一项回顾性研究，并对文献进行了回顾。结果文献分析强化了从纳入的16名患者中获得的主要结论：（i）产气荚膜梭状芽孢杆菌是最常见的受累物种，（ii）患者在假体放置和感染时年龄较大，（iii）大多数感染是早发或迟发，（iv）这些PJI的预后仍然较差，（v）当进行（n=5）时，DAIR和12周的抗菌治疗在80%的病例中产生了良好的结果。结论鉴于这种感染的发病率较低，我们的工作代表了迄今为止报道的最大的梭菌PJI系列，并强调了这些感染的一些特异性。需要进一步的前瞻性研究来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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