Correlation of microsatellite status and EBV infection with clinical characteristics of patients with gastric cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.4149/gpb_2023021

Pengfei Lu, Kadeliya Yushan, Gulimilai Yusufu, Hiu Wang, Rui Mao

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Abstract

This study was designed to investigate the correlation of microsatellite status (MS) and Epstein-Barr virus (EBV) infection with the clinical characteristics of gastric cancer (GC) patients. MS was detected by immunohistochemistry. EBV was detected by in situ hybridization. There were 31.3% cases showed mismatch repair-deficient (dMMR)/ microsatellite instability (MSI) and 68.7% cases showed mismatch repair-proficient (pMMR)/ microsatellite stability (MSS). The dMMR/MSI was more common in the elderly, in patients with cardia GC, smaller tumor diameter or non-poorly differentiated carcinoma. The survival in dMMR/MSI patients tended to be longer than that in pMMR/MSS patients. Total 7.6% cases showed EBV-positive (EBV(+)) among 198 GC patients. EBV(+) was more common in patients with advanced GC or poorly differentiated adenocarcinoma. MSI was more common in EBV-negative (EBV(-)) patients than in EBV(+) patients. The dMMR/MSI patients with stage II GC benefited from chemotherapy. The survival of EBV(+) patients tended to be longer than that of EBV(-) patients.

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微卫星状态和EBV感染与胃癌患者临床特征的相关性研究。

本研究旨在探讨微卫星状态(MS)和eb病毒(EBV)感染与胃癌(GC)患者临床特征的相关性。免疫组织化学检测MS。用原位杂交法检测EBV。31.3%的患者表现为错配修复缺陷(dMMR)/微卫星不稳定性(MSI)， 68.7%的患者表现为错配修复熟练(pMMR)/微卫星稳定性(MSS)。dMMR/MSI在老年人、贲门GC、较小肿瘤直径或非低分化癌患者中更为常见。dMMR/MSI患者的生存期往往长于pMMR/MSS患者。198例GC患者中EBV阳性(EBV(+))占7.6%。EBV(+)在晚期胃癌或低分化腺癌患者中更为常见。MSI在EBV阴性(EBV(-))患者中比在EBV(+)患者中更常见。dMMR/MSI II期GC患者受益于化疗。EBV(+)患者的生存期往往长于EBV(-)患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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