Tumorigenesis mechanism and application strategy of the MDCK cell line: A systematic review

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-08-01 DOI:10.1016/j.biologicals.2023.101699

Di Yang , Lingwei Huang , Jiamin Wang , Huihao Wu , Zhenbin Liu , Ayimuguli Abudureyimu , Zilin Qiao

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Abstract

Influenza is an acute respiratory infectious disease caused by influenza virus that seriously endangers people's health. Influenza vaccination is the most effective means to prevent influenza virus infection and its serious complications. MDCK cells are considered to be superior to chicken embryos for the production of influenza vaccines, but the tumorigenicity of cells is a concern over the theoretical possibility of the risk of adverse events. The theoretical risks need to be adequately addressed if public confidence in programs of immunization are to be maintained. In this paper, studies of the tumorigenic potential of cell lines, with MDCK cells as an example, published since 2010 are reviewed. The mechanism of tumorigenicity of MDCK cells is discussed with reference to cell heterogeneity and epithelial to mesenchymal transition (EMT). Understanding the mechanism of the acquisition of a tumorigenic phenotype by MDCK cells might assist in estimating potential risks associated with using tumorigenic cell substrates for vaccine production.

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MDCK细胞系的肿瘤发生机制及应用策略综述

流感是由流感病毒引起的严重危害人体健康的急性呼吸道传染病。接种流感疫苗是预防流感病毒感染及其严重并发症的最有效手段。MDCK细胞被认为在生产流感疫苗方面优于鸡胚，但细胞的致瘤性令人担忧的是不良事件风险的理论可能性。如果要保持公众对免疫计划的信心，就需要充分解决理论风险。本文综述了自2010年以来发表的以MDCK细胞为例的细胞系致瘤潜力的研究。结合细胞异质性和上皮-间充质转化（EMT），探讨了MDCK细胞致瘤性的机制。了解MDCK细胞获得致瘤表型的机制可能有助于估计使用致瘤细胞底物生产疫苗的潜在风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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