Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology Advances in protein chemistry and structural biology Pub Date : 2023-01-01 DOI:10.1016/bs.apcsb.2023.02.013

Priyanka Sarkar, Ashish Kumar, Partha Sarathi Behera, Kavitha Thirumurugan

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Abstract

Neurodegenerative diseases are characterized by degeneration or cellular atrophy within specific structures of the brain. Neurons are the major target of neurodegeneration. Neurons utilize 75-80% of the energy produced in the brain. This energy is either formed by utilizing the glucose provided by the cerebrovascular blood flow or by the in-house energy producers, mitochondria. Mitochondrial dysfunction has been associated with neurodegenerative diseases. But recently it has been noticed that neurodegenerative diseases are often associated with cerebrovascular diseases. Cerebral blood flow requires vasodilation which to an extent regulated by mitochondria. We hypothesize that when mitochondrial functioning is disrupted, it is not able to supply energy to the neurons. This disruption also affects cerebral blood flow, further reducing the possibilities of energy supply. Loss of sufficient energy leads to neuronal dysfunction, atrophy, and degeneration. In this chapter, we will discuss the metabolic modifications of mitochondria in aging-related neurological disorders and the potential of phytocompounds targeting them.

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神经退行性疾病中线粒体的植物治疗靶向。

神经退行性疾病的特征是大脑特定结构的退化或细胞萎缩。神经元是神经变性的主要目标。神经元利用大脑中产生的75-80%的能量。这种能量要么是通过利用脑血管血流提供的葡萄糖形成的，要么是由体内的能量生产者线粒体形成的。线粒体功能障碍与神经退行性疾病有关。但近年来人们注意到神经退行性疾病常与脑血管疾病相关。脑血流需要血管舒张，这在一定程度上由线粒体调节。我们假设，当线粒体功能被破坏时，它不能向神经元提供能量。这种破坏也会影响脑血流量，进一步减少能量供应的可能性。缺乏足够的能量会导致神经元功能障碍、萎缩和退化。在本章中，我们将讨论衰老相关神经系统疾病中线粒体的代谢改变以及靶向它们的植物化合物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

7.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.