Effects of acute aerobic exercise on brain-derived neurotrophic factor level in rheumatoid arthritis patients.

IF 1.1 4区医学 Q4 Medicine Archives of rheumatology Pub Date : 2023-06-01 DOI:10.46497/ArchRheumatol.2023.9599

Songül Bağlan Yentur, Zübeyde Ercan, Gülnihal Deniz, Ahmet Karataş, Mustafa Gür, Gökhan Alkan, Süleyman Serdar Koca

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Abstract

Objectives: The study aimed to investigate the variation of brain-derived neurotrophic factor (BDNF) levels following acute exercise in patients with rheumatoid arthritis (RA).

Patients and methods: This cross-sectional study was conducted with 88 participants (25 males, 63 females; mean age: 45.1±8.3 years; range, 18 to 65 years) between July 2020 and May 2021. Of the participants, 44 were RA patients, and 44 were age-and sex-matched healthy controls. Aerobic exercise was utilized in all participants for a single session. Depression and anxiety levels were evaluated with the Beck Depression Inventory and Hospital Anxiety and Depression Scale. Blood samples were collected from all subjects before and immediately after the intervention.

Results: Serum BDNF levels (both baseline and after exercise) were similar in the RA and control groups. Although serum BDNF levels significantly decreased in both groups after aerobic exercise (Wilcoxon rank p<0.05), ΔBDNF levels were significantly higher in the RA group than in the control group (p=0.047). Additionally, ΔBDNF levels were significantly correlated with the Hospital Anxiety and Depression Scale scores in the RA group (p<0.05) but not in the control group.

Conclusion: A single bout of exercise may effectively decrease serum BDNF levels in patients with RA and healthy subjects. The long-term effect of exercise on BDNF levels should be investigated in prospective studies.

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急性有氧运动对类风湿关节炎患者脑源性神经营养因子水平的影响

目的:研究类风湿关节炎(RA)患者急性运动后脑源性神经营养因子(BDNF)水平的变化。患者和方法:本横断面研究共纳入88名参与者(25名男性，63名女性;平均年龄:45.1±8.3岁;从2020年7月到2021年5月。在参与者中，44人是类风湿性关节炎患者，44人是年龄和性别匹配的健康对照。所有参与者都进行了一次有氧运动。采用贝克抑郁量表和医院焦虑抑郁量表评估抑郁和焦虑水平。在干预前和干预后立即采集所有受试者的血液样本。结果:RA组和对照组的血清BDNF水平(基线和运动后)相似。结论:单次运动可有效降低RA患者和健康受试者的血清BDNF水平。运动对BDNF水平的长期影响应在前瞻性研究中进行调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of rheumatology Medicine-Rheumatology

CiteScore

2.00

自引率

9.10%

发文量

期刊介绍： The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).