Detection strategies for elevated lipoprotein(a): will implementation let the genie out of the bottle?

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Current Opinion in Endocrinology & Diabetes and Obesity Pub Date : 2023-04-01 DOI:10.1097/MED.0000000000000789

Wann Jia Loh, Gerald F Watts

{"title":"Detection strategies for elevated lipoprotein(a): will implementation let the genie out of the bottle?","authors":"Wann Jia Loh, Gerald F Watts","doi":"10.1097/MED.0000000000000789","DOIUrl":null,"url":null,"abstract":"Purpose of review: Elevated Lp(a) level is an important causal risk factor for atherosclerotic cardiovascular disease (ASCVD), principally coronary artery disease. Selective testing for Lp(a) is highly recommended in patients at intermediate and high risk for ASCVD. Lp(a) levels are predominantly genetically determined, and this has implications for cascade testing.Recent findings: Recent studies show that cascade testing is effective in identifying elevated Lp(a) in close relatives of probands with high Lp(a). Apart from selective testing and cascade testing as detection strategies, some recent guidelines recommend testing of Lp(a) in all adults at least once in their lifetime and various implementation strategies have been suggested.Summary: Hyper-Lp(a) is an important global health problem that can be easily detected. Hyper-Lp(a) meets all the criteria for universal screening except that there is not yet supportive evidence from clinical interventional trials showing a reduction of ASCVD events. The cost-effectiveness of the various detection and implementation strategies need to be further evaluated.","PeriodicalId":10964,"journal":{"name":"Current Opinion in Endocrinology & Diabetes and Obesity","volume":"30 2","pages":"94-102"},"PeriodicalIF":2.6000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Endocrinology & Diabetes and Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MED.0000000000000789","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 2

Abstract

Purpose of review: Elevated Lp(a) level is an important causal risk factor for atherosclerotic cardiovascular disease (ASCVD), principally coronary artery disease. Selective testing for Lp(a) is highly recommended in patients at intermediate and high risk for ASCVD. Lp(a) levels are predominantly genetically determined, and this has implications for cascade testing.

Recent findings: Recent studies show that cascade testing is effective in identifying elevated Lp(a) in close relatives of probands with high Lp(a). Apart from selective testing and cascade testing as detection strategies, some recent guidelines recommend testing of Lp(a) in all adults at least once in their lifetime and various implementation strategies have been suggested.

Summary: Hyper-Lp(a) is an important global health problem that can be easily detected. Hyper-Lp(a) meets all the criteria for universal screening except that there is not yet supportive evidence from clinical interventional trials showing a reduction of ASCVD events. The cost-effectiveness of the various detection and implementation strategies need to be further evaluated.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

脂蛋白升高的检测策略(a):实施会让妖怪从瓶子里出来吗?

综述目的:脂蛋白(a)水平升高是动脉粥样硬化性心血管疾病(ASCVD)，主要是冠状动脉疾病的重要危险因素。在ASCVD中、高风险患者中，强烈推荐选择性检测Lp(a)。Lp(a)水平主要是由基因决定的，这对级联检测有影响。最近的发现:最近的研究表明，级联检测在高Lp(a)先证者的近亲中检测高Lp(a)是有效的。除了选择性检测和级联检测作为检测策略外，最近的一些指南建议所有成年人一生中至少进行一次Lp(a)检测，并提出了各种实施策略。摘要:Hyper-Lp(a)是一个很容易发现的重要全球健康问题。Hyper-Lp(a)符合普遍筛查的所有标准，除了尚未有临床介入性试验的支持性证据显示ASCVD事件的减少。需要进一步评价各种检测和执行战略的成本效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Opinion in Endocrinology & Diabetes and Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

5.80

自引率

3.10%

发文量

128

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Endocrinology, Diabetes and Obesity delivers a broad-based perspective on the most recent and exciting developments in the field from across the world. Published bimonthly and featuring twelve key topics – including androgens, gastrointestinal hormones, diabetes and the endocrine pancreas, and neuroendocrinology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.

期刊最新文献

Indications for testosterone therapy in men. Testosterone and male contraception. Time to cycle regularity and health risks. Male infertility and obesity. Testosterone and the prevention of type 2 diabetes mellitus: therapeutic implications from recent trials.