Offline 20 Hz transcranial alternating current stimulation over the right inferior frontal gyrus increases theta activity during a motor response inhibition task

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2023-06-01 DOI:10.1016/j.neucli.2023.102887

Ekaterina Lyzhko , Stefanie E. Peter , Frauke Nees , Michael Siniatchkin , Vera Moliadze

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Abstract

Objectives

Previous studies have shown that the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (preSMA) play an important role in motor inhibitory control. The aim of the study was to use theta frequency transcranial alternating current stimulation (tACS) to modulate brain activity in the rIFG and preSMA and to test the effects of stimulation using a motor response inhibition task.

Methods

In four sessions, 20 healthy participants received tACS at 6 Hz over preSMA or rIFG, or 20 Hz over rIFG (to test frequency specificity), or sham stimulation before task processing. After each type of stimulation, the participants performed the Go/NoGo task with simultaneous electroencephalogram (EEG) recording.

Results

By stimulating rIFG and preSMA with 6 Hz tACS, we were not able to modulate either behavioral performance nor the EEG correlate. Interestingly, 20 Hz tACS over the rIFG significantly increased theta activity, however without behavioral effects. This increased theta activity did not coincide with the stimulation area and was localized in the fronto-central and centro-parietal areas.

Conclusions

The inclusion of a control frequency is crucial to test for frequency specificity. Our findings are in accordance with previous studies showing that after effects of tACS are not restricted to the stimulation frequency but can also occur in other frequency bands.

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在运动反应抑制任务中，右额下回上的离线20赫兹经颅交流电刺激增加了θ活动

目的先前的研究表明，右额下回（rIFG）和补充运动前区（preSMA）在运动抑制控制中起着重要作用。该研究的目的是使用θ频率经颅交流刺激（tACS）来调节rIFG和preSMA中的大脑活动，并使用运动反应抑制任务来测试刺激的效果。方法在四个疗程中，20名健康参与者在任务处理前接受6 Hz的tSMA或rIFG，或20 Hz的rIFG（测试频率特异性）或假刺激。在每种类型的刺激之后，参与者执行Go/NoGo任务，同时进行脑电图（EEG）记录。结果用6Hz tACS刺激rIFG和preSMA，我们既不能调节行为表现，也不能调节EEG的相关性。有趣的是，rIFG上的20 Hz tACS显著增加了θ活性，但没有行为影响。这种增加的θ活动与刺激区域不一致，并且局限于额中央和顶叶中央区域。结论纳入对照频率对于检测频率特异性至关重要。我们的研究结果与先前的研究一致，表明tACS的后遗症不仅限于刺激频率，也可能发生在其他频带。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.