Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-02-01 Epub Date: 2023-09-16 DOI:10.1007/s11154-023-09836-y
Alessio Imperiale, Valentina Berti, Mickaël Burgy, Roberto Luigi Cazzato, Arnoldo Piccardo, Giorgio Treglia
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Abstract

Due to its rarity and non-specific clinical presentation, accurate diagnosis, and optimal therapeutic strategy of medullary thyroid carcinoma (MTC) remain challenging. Molecular imaging provides valuable tools for early disease detection, monitoring treatment response, and guiding personalized therapies. By enabling the visualization of molecular and cellular processes, these techniques contribute to a deeper understanding of disease mechanisms and the development of more effective clinical interventions. Different nuclear imaging techniques have been studied for assessing MTC, and among them, PET/CT utilizing multiple radiotracers has emerged as the most effective imaging method in clinical practice. This review aims to provide a comprehensive summary of the current use of advanced molecular imaging modalities, with a particular focus on PET/CT, for the management of patients with MTC. It aims to guide physicians towards a rationale for the use of molecular imaging also including theranostic approaches and novel therapeutical opportunities. Overall, we emphasize the evolving role of nuclear medicine in MTC. The integration of diagnostics and therapeutics by in vivo molecular imaging represents a major opportunity to personalize treatment for individual patients, with targeted radionuclide therapy being one representative example.

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甲状腺髓样癌的分子成像和相关治疗方案:技术现状与未来机遇。
由于甲状腺髓样癌(MTC)的罕见性和非特异性临床表现,其准确诊断和最佳治疗策略仍具有挑战性。分子成像为早期疾病检测、监测治疗反应和指导个性化疗法提供了宝贵的工具。通过将分子和细胞过程可视化,这些技术有助于加深对疾病机制的理解,并开发出更有效的临床干预措施。目前已研究出不同的核成像技术用于评估 MTC,其中利用多种放射性核素的 PET/CT 已成为临床实践中最有效的成像方法。本综述旨在全面总结目前在 MTC 患者管理中使用先进分子成像模式的情况,尤其侧重于 PET/CT。它旨在引导医生了解分子成像的使用原理,包括治疗方法和新的治疗机会。总之,我们强调核医学在 MTC 中不断发展的作用。活体分子成像将诊断和治疗结合在一起,为患者的个性化治疗提供了重要机会,放射性核素靶向治疗就是一个很有代表性的例子。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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